Subcortical vascular lesions and functional recovery in older patients with gait disorders

Fabio Guerini, Giovanni Battista Frisoni, Giuseppe Bellelli, Marco Trabucchi

Research output: Contribution to journalArticlepeer-review


This study aimed to assess whether subcortical vascular lesions (SVLs) predict functional recovery after rehabilitation in elderly patients with gait disorders (GD) due to multiple etiology (GD-ME). All patients consecutively admitted with GD-ME (n = 103) in our Rehabilitation and Aged Care Unit (RACU) underwent a standardized rehabilitative program. The outcome measure was the Barthel Index (BI) Relative Functional Gain (RFG), a measure of improvement adjusting for baseline functional level. Potential predictors included cognition, depression, functional and nutritional status, physical health, occurrence of adverse clinical events during hospital stay, and SVLs, assessed with a validated visual rating scale based on brain CT scans. Predictors were divided into quartiles and the association with RFG was assessed. In a multivariate linear regression model, SVLs maintained its predictive power on RFG after adjustment for age, gender, and adverse clinical events, which was the only variable associated to RFG in the bivariate model (adjusted p = 0.002 for trend). The study shows that SVLs is a predictor of functional recovery in elderly patients with GD-ME.

Original languageEnglish
Pages (from-to)87-96
Number of pages10
JournalArchives of Gerontology and Geriatrics
Issue number1
Publication statusPublished - Jul 2007


  • Functional recovery
  • GD in elderly
  • SVLs

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)


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