Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain

P. G. Crosignani, A. Luciano, Amrit Ray, A. Bergqvist

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A clinical study compared efficacy and safety of depot medroxyprogesterone acetate (DMPA) with leuprolide for endometriosis-associated pain. Methods: This multicentre, 18 month, evaluator-blinded, comparator-controlled trial randomized 300 women with laparoscopically diagnosed endometriosis to 6 month treatment with subcutaneous injection of 104 mg/0.65 ml DMPA (DMPA-SC 104) every 3 months or leuprolide (3.75 mg monthly or 11.25 mg every 3 months), with 12 months post-treatment follow-up. Endpoints included patient response to treatment in five signs/symptoms (dysmenorrhoea, dyspareunia, pelvic pain, pelvic tenderness, induration) and changes in bone mineral density (BMD) and productivity at 6 and 18 months. Results: DMPA-SC 104 and leuprolide produced equivalent (P <0.02) reductions in at least four pain categories and significant (P <0.001) improvements in composite score at months 6 and 18. At month 6, reductions in total hip and lumbar spine BMD were significantly less (P <0.001) with DMPA-SC 104 versus leuprolide. BMD returned to pre-treatment levels 12 months post-treatment in the DMPA-SC 104 but not the leuprolide group. Total productivity also significantly (P≤0.05) improved in both groups at 6 and 18 months. Conclusions: DMPA-SC 104 reduces endometriosis-associated pain as effectively as leuprolide and improves productivity with significantly less BMD decline.

Original languageEnglish
Pages (from-to)248-256
Number of pages9
JournalHuman Reproduction
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 2006

Keywords

  • Bone mineral density
  • Depot medroxyprogesterone acetate
  • Endometriosis
  • Leuprolide
  • Pelvic pain
  • Subcutaneous injection

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

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