Subcutaneous Ewing sarcoma/PNET as a second cancer in a previously irradiated young patient. An uncommon type of post-irradiation soft tissue sarcoma

M. Bruno, G. I. D'Antona, G. Vita, G. Perrone, F. Fiordelisi, M. Bisceglia

Research output: Contribution to journalArticle


Soft tissue sarcomas account for a small proportion of second cancers, with an estimated frequency of <10%. The most common histologic type of soft tissue sarcomas as second cancers include mostly high-grade sarcomas, such as rhabdomyosarcoma, malignant peripheral nerve sheath tumour, fibrosarcoma, leiomyosarcoma, synovial sarcoma, alveolar soft part sarcoma and Ewing sarcoma/primitive neuroectodermal tumour (PNET). We report a case of superficial soft tissue Ewing sarcoma/PNET as a second cancer in a young patient previously treated for Hodgkin's disease (HD). To the best of our knowledge and based on a literature search, this is the first reported case of post-irradiation soft tissue Ewing sarcoma/PNET as a second cancer arising in the same area irradiated for cure of HD.

Original languageEnglish
Pages (from-to)43-45
Number of pages3
Issue number2
Publication statusPublished - Apr 2011



  • Ewing's sarcoma
  • Hodgkin's disease
  • Peripheral neuroectodermal tumor
  • Post-irradiation sarcoma
  • Second cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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