Subcutaneous immunoglobulin in CIDP and MMN: a short-term nationwide study

Dario Cocito, Aristide Merola, Erdita Peci, Anna Mazzeo, Raffaella Fazio, Ada Francia, Paola Valentino, Rocco Liguori, Massimiliano Filosto, Gabriele Siciliano, Angelo Maurizio Clerici, Stefania Lelli, Girolama Alessandra Marfia, Giovanni Antonini, Ilaria Cecconi, Eduardo Nobile-Orazio, Leonardo Lopiano

Research output: Contribution to journalArticle

Abstract

This multi-center Italian prospective observational study reports the 4 months follow-up data of 87 patients affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) shifted from intravenous to subcutaneous immunoglobulin treatment. A therapeutic shift from intravenous to subcutaneous immunoglobulin was performed in 87 patients (66 CIDP; 21 MMN) affected by immune-mediated peripheral neuropathies with evidence of a sustained clinical response to intravenous immunoglobulin. Patients were evaluated by means of the Overall Neuropathy Limitation Scale, Medical Research Council Scale and Life Quality Index questionnaire, both at the time of therapeutic shift and after 4 months of subcutaneous immunoglobulin treatment. A sustained clinical efficacy was observed after the switch to subcutaneous immunoglobulin: the Overall Neuropathy Limitation Scale score improved in the group of 66 CIDP patients (P = 0.018), with only one subject reporting a worsening of 1 point, and remained stable in the group of 21 MMN patients (P = 0.841), with one subject reporting a worsening of two points. An improvement in the patient’s perception of therapeutic setting was reported in both groups. This large multi-center study confirms the short-term clinical equivalence of subcutaneous versus intravenous immunoglobulin and a possible improvement in the patient’s perception of therapeutic setting with the subcutaneous administration. However, further studies are required to extend the results to a longer observational period.

Original languageEnglish
Pages (from-to)2159-2164
Number of pages6
JournalJournal of Neurology
Volume261
Issue number11
DOIs
Publication statusPublished - 2014

Keywords

  • Chronic inflammatory demyelinating polyneuropathy
  • Inflammatory neuropathy
  • Intravenous immunoglobulin
  • Multifocal motor neuropathy
  • Subcutaneous immunoglobulin

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

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