Subcutaneous xenotransplantation of bovine pancreatic islets

Marina Figliuzzi, Roberta Cornolti, Tiziana Plati, Navneeta Rajan, Federica Adobati, Giuseppe Remuzzi, Andrea Remuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Transplantation of pancreatic islets in diabetes is currently limited by the need of immunosuppressive therapy. The present study was designed to test an immunoprotection planar device for subcutaneous xenotransplantation of pancreatic islets in the diabetic rat. We tested three different devices made of polyethersulfone hollow fibers. In all diabetic rats, implantation of islet-containing devices promptly normalized hyperglycemia. In vitro membrane permeability to glucose was correlated with implant function duration. These data confirm that bovine islets contained within devices and implanted subcutaneously remain functional for several days. Strategies to prolong islet function may allow achieving successful long-term islet implantation in this attractive site.

Original languageEnglish
Pages (from-to)5640-5647
Number of pages8
JournalBiomaterials
Volume26
Issue number28
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Hollow fibers
  • Immunoisolation device
  • Pancreatic islets
  • Subcutaneous site
  • Xenotransplantation

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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