Subdural fluid collections in patients with infantile neuronal ceroid lipofuscinosis

Sondra W. Levin, Eva H. Baker, Andrea Gropman, Zenaide Quezado, Ning Miao, Zhongjian Zhang, Alice Jollands, Matteo Di Capua, Rafael Caruso, Anil B. Mukherjee

Research output: Contribution to journalArticlepeer-review


Objective: To describe subdural fluid collections on magnetic resonance imaging as part of the natural history of infantile neuronal ceroid lipofuscinosis. Design: Case series. Setting: Program on Developmental Endocrinology and Genetics, The Clinical Center, National Institutes of Health, Bethesda, Maryland. Patients: Patients with infantile neuronal ceroid lipofuscinosis with subdural fluid collections. Main Outcome Measure: Neurodegeneration on magnetic resonance imaging. Results: During an ongoing bench-to-bedside clinical investigation, magnetic resonance imaging examinations led to the incidental discovery of subdural fluid collections in 4 of 9 patients with infantile neuronal ceroid lipofuscinosis. No particular event (such as trauma) or change in symptoms was linked to this finding, which was already in the chronic phase when discovered. Of the 4 patients, 1 was followed up for 7 years, 2 for 4 years, and 1 for 2.5 years. Over time, these collections remained stable or decreased in size. Conclusion: Recognition that subdural fluid collections are part of the infantile neuronal ceroid lipofuscinosis disease process may obviate the necessity of additional workup as well as therapeutic interventions in these chronically sick children.

Original languageEnglish
Pages (from-to)1567-1571
Number of pages5
JournalArchives of Neurology
Issue number12
Publication statusPublished - Dec 2009

ASJC Scopus subject areas

  • Clinical Neurology


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