Subfoveal choroidal blood flow and central retinal function in retinitis pigmentosa

Benedetto Falsini, Gian Mario Anselmi, Dario Marangoni, Fabiana D'Esposito, Antonello Fadda, Antonio di Renzo, Emilio C. Campos, Charles E. Riva

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE. To determine whether subfoveal choroidal blood flow is altered in retinitis pigmentosa (RP) and whether this alteration is associated with central cone-mediated dysfunction. METHODS. In 31 RP patients (age range, 15-72 years) with preserved visual acuity (range: 20/30-20/20), subfoveal choroidal blood flow was measured by real-time, confocal laser Doppler flowmetry, and focal macular (18°) electroretinograms(FERGs) were elicited by 41 Hz flickering stimuli. Twenty normal subjects served as controls. The following average blood flow parameters were determined based on three 60-second recordings: volume (ChBVol), velocity (ChBVel), and flow (ChBF), the last being proportional to blood flow if the hematocrit remains constant. The amplitude and phase of the FERG first harmonic component were measured. RESULTS. On average, ChBF and ChBVel were reduced by 26% (P ≤0.02) in RP patients compared to controls, whereas ChBVol was similar in the two groups. FERG amplitudes were reduced by 60% (P _ 0.01) in patients compared with controls. FERG phases of patients tended to be delayed (P

Original languageEnglish
Pages (from-to)1064-1069
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume52
Issue number2
DOIs
Publication statusPublished - Feb 2011

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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