TY - JOUR
T1 - Subfoveal choroidal blood flow and central retinal function in retinitis pigmentosa
AU - Falsini, Benedetto
AU - Anselmi, Gian Mario
AU - Marangoni, Dario
AU - D'Esposito, Fabiana
AU - Fadda, Antonello
AU - di Renzo, Antonio
AU - Campos, Emilio C.
AU - Riva, Charles E.
PY - 2011/2
Y1 - 2011/2
N2 - PURPOSE. To determine whether subfoveal choroidal blood flow is altered in retinitis pigmentosa (RP) and whether this alteration is associated with central cone-mediated dysfunction. METHODS. In 31 RP patients (age range, 15-72 years) with preserved visual acuity (range: 20/30-20/20), subfoveal choroidal blood flow was measured by real-time, confocal laser Doppler flowmetry, and focal macular (18°) electroretinograms(FERGs) were elicited by 41 Hz flickering stimuli. Twenty normal subjects served as controls. The following average blood flow parameters were determined based on three 60-second recordings: volume (ChBVol), velocity (ChBVel), and flow (ChBF), the last being proportional to blood flow if the hematocrit remains constant. The amplitude and phase of the FERG first harmonic component were measured. RESULTS. On average, ChBF and ChBVel were reduced by 26% (P ≤0.02) in RP patients compared to controls, whereas ChBVol was similar in the two groups. FERG amplitudes were reduced by 60% (P _ 0.01) in patients compared with controls. FERG phases of patients tended to be delayed (P
AB - PURPOSE. To determine whether subfoveal choroidal blood flow is altered in retinitis pigmentosa (RP) and whether this alteration is associated with central cone-mediated dysfunction. METHODS. In 31 RP patients (age range, 15-72 years) with preserved visual acuity (range: 20/30-20/20), subfoveal choroidal blood flow was measured by real-time, confocal laser Doppler flowmetry, and focal macular (18°) electroretinograms(FERGs) were elicited by 41 Hz flickering stimuli. Twenty normal subjects served as controls. The following average blood flow parameters were determined based on three 60-second recordings: volume (ChBVol), velocity (ChBVel), and flow (ChBF), the last being proportional to blood flow if the hematocrit remains constant. The amplitude and phase of the FERG first harmonic component were measured. RESULTS. On average, ChBF and ChBVel were reduced by 26% (P ≤0.02) in RP patients compared to controls, whereas ChBVol was similar in the two groups. FERG amplitudes were reduced by 60% (P _ 0.01) in patients compared with controls. FERG phases of patients tended to be delayed (P
UR - http://www.scopus.com/inward/record.url?scp=79953286119&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953286119&partnerID=8YFLogxK
U2 - 10.1167/iovs.10-5964
DO - 10.1167/iovs.10-5964
M3 - Article
C2 - 20861481
AN - SCOPUS:79953286119
VL - 52
SP - 1064
EP - 1069
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 2
ER -