Subinhibitory concentrations of moxifloxacin decrease adhesion and biofilm formation of Stenotrophomonas maltophilia from cystic fibrosis

A. Pompilio, C. Catavitello, C. Picciani, P. Confalone, R. Piccolomini, V. Savini, E. Fiscarelli, D. D'Antonio, G. Di Bonaventura

Research output: Contribution to journalArticle

Abstract

Stenotrophomonas maltophilia is an emerging nosocomial bacterial pathogen that is currently isolated with increasing frequency from the airways of cystic fibrosis (CF) patients. In this study the effect of subinhibitory concentrations (subMICs) of moxifloxacin on adhesion, biofilm formation and cell-surface hydrophobicity of two strains of S. maltophilia isolated from CF patients were evaluated. Adhesion and biofilm formation assays were carried out on polystyrene and quantified by colony counts. Cell-surface hydrophobicity was determined by a test for adhesion to n-hexadecane. Moxifloxacin at 0.03x and 0.06x MIC caused a significant decrease in adhesion and biofilm formation by both strains tested. A significant reduction in cell-surface hydrophobicity following exposure to subMICs of moxifloxacin was observed for one strain only. The results of the present study provide an additional rationale for the use of moxifloxacin in CF patients and more generally in biofilm-related infections involving S. maltophilia.

Original languageEnglish
Pages (from-to)76-81
Number of pages6
JournalJournal of Medical Microbiology
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Stenotrophomonas maltophilia
Biofilms
Cystic Fibrosis
Hydrophobic and Hydrophilic Interactions
Polystyrenes
moxifloxacin
Infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Pompilio, A., Catavitello, C., Picciani, C., Confalone, P., Piccolomini, R., Savini, V., ... Di Bonaventura, G. (2010). Subinhibitory concentrations of moxifloxacin decrease adhesion and biofilm formation of Stenotrophomonas maltophilia from cystic fibrosis. Journal of Medical Microbiology, 59(1), 76-81. https://doi.org/10.1099/jmm.0.011981-0

Subinhibitory concentrations of moxifloxacin decrease adhesion and biofilm formation of Stenotrophomonas maltophilia from cystic fibrosis. / Pompilio, A.; Catavitello, C.; Picciani, C.; Confalone, P.; Piccolomini, R.; Savini, V.; Fiscarelli, E.; D'Antonio, D.; Di Bonaventura, G.

In: Journal of Medical Microbiology, Vol. 59, No. 1, 01.2010, p. 76-81.

Research output: Contribution to journalArticle

Pompilio, A, Catavitello, C, Picciani, C, Confalone, P, Piccolomini, R, Savini, V, Fiscarelli, E, D'Antonio, D & Di Bonaventura, G 2010, 'Subinhibitory concentrations of moxifloxacin decrease adhesion and biofilm formation of Stenotrophomonas maltophilia from cystic fibrosis', Journal of Medical Microbiology, vol. 59, no. 1, pp. 76-81. https://doi.org/10.1099/jmm.0.011981-0
Pompilio, A. ; Catavitello, C. ; Picciani, C. ; Confalone, P. ; Piccolomini, R. ; Savini, V. ; Fiscarelli, E. ; D'Antonio, D. ; Di Bonaventura, G. / Subinhibitory concentrations of moxifloxacin decrease adhesion and biofilm formation of Stenotrophomonas maltophilia from cystic fibrosis. In: Journal of Medical Microbiology. 2010 ; Vol. 59, No. 1. pp. 76-81.
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