Abstract
The prediction of the stress-state and fracture risk induced in bones by various loading conditions in individual patients using subject-specific finite element models still represents a challenge in orthopaedic biomechanics. The accuracy of the strain predictions reported in the literature is variable and generally not satisfactory. The aim of the present study was to evaluate if a proper choice of the density-elasticity relationship can lead to accurate strain predictions in the frame of an automatic subject-specific model generation strategy. To this aim, a combined numerical-experimental study was performed comparing finite element predicted strains with strain-gauges measurements obtained on eight cadaver proximal femurs, each instrumented with 15 rosettes mostly concentrated in the bone metaphyses, tested non-destructively in vitro under six different loading scenarios. Three different density-elasticity power relationships were selected from the literature and implemented in the finite element models derived from computed tomography data. The results of the present study confirm the great influence of the density-elasticity relationship used on the accuracy of numerical predictions. One of the tested constitutive laws provided a very good agreement (R2=0.91, RMSE lower than 10% of the maximum measured value) between numerical calculations and experimental measurements. The presented results show, in addition, that the adoption of a single density-elasticity relationship over the whole bone density range is adequate to obtain an accuracy that is already suitable for many applications.
| Original language | English |
|---|---|
| Pages (from-to) | 2982-2989 |
| Number of pages | 8 |
| Journal | Journal of Biomechanics |
| Volume | 40 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - 2007 |
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Keywords
- Automatic mesh generation
- Computed tomography
- Density-elasticity relationship
- Experimental validation
- Subject-specific finite element modelling
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
Cite this
Subject-specific finite element models can accurately predict strain levels in long bones. / Schileo, Enrico; Taddei, Fulvia; Malandrino, Andrea; Cristofolini, Luca; Viceconti, Marco.
In: Journal of Biomechanics, Vol. 40, No. 13, 2007, p. 2982-2989.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subject-specific finite element models can accurately predict strain levels in long bones
AU - Schileo, Enrico
AU - Taddei, Fulvia
AU - Malandrino, Andrea
AU - Cristofolini, Luca
AU - Viceconti, Marco
PY - 2007
Y1 - 2007
N2 - The prediction of the stress-state and fracture risk induced in bones by various loading conditions in individual patients using subject-specific finite element models still represents a challenge in orthopaedic biomechanics. The accuracy of the strain predictions reported in the literature is variable and generally not satisfactory. The aim of the present study was to evaluate if a proper choice of the density-elasticity relationship can lead to accurate strain predictions in the frame of an automatic subject-specific model generation strategy. To this aim, a combined numerical-experimental study was performed comparing finite element predicted strains with strain-gauges measurements obtained on eight cadaver proximal femurs, each instrumented with 15 rosettes mostly concentrated in the bone metaphyses, tested non-destructively in vitro under six different loading scenarios. Three different density-elasticity power relationships were selected from the literature and implemented in the finite element models derived from computed tomography data. The results of the present study confirm the great influence of the density-elasticity relationship used on the accuracy of numerical predictions. One of the tested constitutive laws provided a very good agreement (R2=0.91, RMSE lower than 10% of the maximum measured value) between numerical calculations and experimental measurements. The presented results show, in addition, that the adoption of a single density-elasticity relationship over the whole bone density range is adequate to obtain an accuracy that is already suitable for many applications.
AB - The prediction of the stress-state and fracture risk induced in bones by various loading conditions in individual patients using subject-specific finite element models still represents a challenge in orthopaedic biomechanics. The accuracy of the strain predictions reported in the literature is variable and generally not satisfactory. The aim of the present study was to evaluate if a proper choice of the density-elasticity relationship can lead to accurate strain predictions in the frame of an automatic subject-specific model generation strategy. To this aim, a combined numerical-experimental study was performed comparing finite element predicted strains with strain-gauges measurements obtained on eight cadaver proximal femurs, each instrumented with 15 rosettes mostly concentrated in the bone metaphyses, tested non-destructively in vitro under six different loading scenarios. Three different density-elasticity power relationships were selected from the literature and implemented in the finite element models derived from computed tomography data. The results of the present study confirm the great influence of the density-elasticity relationship used on the accuracy of numerical predictions. One of the tested constitutive laws provided a very good agreement (R2=0.91, RMSE lower than 10% of the maximum measured value) between numerical calculations and experimental measurements. The presented results show, in addition, that the adoption of a single density-elasticity relationship over the whole bone density range is adequate to obtain an accuracy that is already suitable for many applications.
KW - Automatic mesh generation
KW - Computed tomography
KW - Density-elasticity relationship
KW - Experimental validation
KW - Subject-specific finite element modelling
UR - http://www.scopus.com/inward/record.url?scp=34548567395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548567395&partnerID=8YFLogxK
U2 - 10.1016/j.jbiomech.2007.02.010
DO - 10.1016/j.jbiomech.2007.02.010
M3 - Article
C2 - 17434172
AN - SCOPUS:34548567395
VL - 40
SP - 2982
EP - 2989
JO - Journal of Biomechanics
JF - Journal of Biomechanics
SN - 0021-9290
IS - 13
ER -