Sublingual immunotherapy-induced IL-10 production is associated with improvement of nasal airflow resistance

Preliminary report

Giorgio Ciprandi, I. Cirillo, M. A. Tosca, A. C. Negrini, G. Marseglia, D. Fenoglio

Research output: Contribution to journalArticle

Abstract

Background: Sublingual immunotherapy has been demonstrated to be able of inducing a regulatory T cell (Treg) response as evidenced by IL-10 production. Nasal obstruction may be measured by rhinomanometry. Objective: The aim of this study was to assess the association of sublingual immunotherapy-induced IL-10 production with nasal airflow resistances. Methods: 19 patients with perennial allergic rhinitis were studied: 9 successfully assumed sublingual immunotherapy for 3 years, 10 were considered as control. In vitro IL-10 production was evaluated after sublingual immunotherapy. Rhinomanometry was performed in all subjects before and after 3 years. Results: After 3 years, sublingual immunotherapy-patients showed a significant decrease of nasal resistances (0.048). The comparison with non-treated allergic patients shows significant differences (p = 0.02). In addition, the percentages of reversibility were associated with IL-10 levels (p = 0.0016). Conclusions: This study provides the first evidence of an association between improved nasal resistances and Treg-induced IL-10 production after sublingual immunotherapy in patients with perennial allergic rhinitis.

Original languageEnglish
Pages (from-to)164-166
Number of pages3
JournalItalian Journal of Allergy and Clinical Immunology
Volume16
Issue number4
Publication statusPublished - Dec 2006

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Sublingual Immunotherapy
Nose
Interleukin-10
Rhinitis, Allergic, Perennial
Rhinomanometry
Nasal Obstruction
Regulatory T-Lymphocytes

Keywords

  • Allergic rhinitis
  • IL-10
  • Nasal airflow resistance
  • Nasal obstruction
  • Rhinomanometry
  • Sublingual immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

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title = "Sublingual immunotherapy-induced IL-10 production is associated with improvement of nasal airflow resistance: Preliminary report",
abstract = "Background: Sublingual immunotherapy has been demonstrated to be able of inducing a regulatory T cell (Treg) response as evidenced by IL-10 production. Nasal obstruction may be measured by rhinomanometry. Objective: The aim of this study was to assess the association of sublingual immunotherapy-induced IL-10 production with nasal airflow resistances. Methods: 19 patients with perennial allergic rhinitis were studied: 9 successfully assumed sublingual immunotherapy for 3 years, 10 were considered as control. In vitro IL-10 production was evaluated after sublingual immunotherapy. Rhinomanometry was performed in all subjects before and after 3 years. Results: After 3 years, sublingual immunotherapy-patients showed a significant decrease of nasal resistances (0.048). The comparison with non-treated allergic patients shows significant differences (p = 0.02). In addition, the percentages of reversibility were associated with IL-10 levels (p = 0.0016). Conclusions: This study provides the first evidence of an association between improved nasal resistances and Treg-induced IL-10 production after sublingual immunotherapy in patients with perennial allergic rhinitis.",
keywords = "Allergic rhinitis, IL-10, Nasal airflow resistance, Nasal obstruction, Rhinomanometry, Sublingual immunotherapy",
author = "Giorgio Ciprandi and I. Cirillo and Tosca, {M. A.} and Negrini, {A. C.} and G. Marseglia and D. Fenoglio",
year = "2006",
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language = "English",
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pages = "164--166",
journal = "Italian Journal of Allergy and Clinical Immunology",
issn = "1120-6373",
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TY - JOUR

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T2 - Preliminary report

AU - Ciprandi, Giorgio

AU - Cirillo, I.

AU - Tosca, M. A.

AU - Negrini, A. C.

AU - Marseglia, G.

AU - Fenoglio, D.

PY - 2006/12

Y1 - 2006/12

N2 - Background: Sublingual immunotherapy has been demonstrated to be able of inducing a regulatory T cell (Treg) response as evidenced by IL-10 production. Nasal obstruction may be measured by rhinomanometry. Objective: The aim of this study was to assess the association of sublingual immunotherapy-induced IL-10 production with nasal airflow resistances. Methods: 19 patients with perennial allergic rhinitis were studied: 9 successfully assumed sublingual immunotherapy for 3 years, 10 were considered as control. In vitro IL-10 production was evaluated after sublingual immunotherapy. Rhinomanometry was performed in all subjects before and after 3 years. Results: After 3 years, sublingual immunotherapy-patients showed a significant decrease of nasal resistances (0.048). The comparison with non-treated allergic patients shows significant differences (p = 0.02). In addition, the percentages of reversibility were associated with IL-10 levels (p = 0.0016). Conclusions: This study provides the first evidence of an association between improved nasal resistances and Treg-induced IL-10 production after sublingual immunotherapy in patients with perennial allergic rhinitis.

AB - Background: Sublingual immunotherapy has been demonstrated to be able of inducing a regulatory T cell (Treg) response as evidenced by IL-10 production. Nasal obstruction may be measured by rhinomanometry. Objective: The aim of this study was to assess the association of sublingual immunotherapy-induced IL-10 production with nasal airflow resistances. Methods: 19 patients with perennial allergic rhinitis were studied: 9 successfully assumed sublingual immunotherapy for 3 years, 10 were considered as control. In vitro IL-10 production was evaluated after sublingual immunotherapy. Rhinomanometry was performed in all subjects before and after 3 years. Results: After 3 years, sublingual immunotherapy-patients showed a significant decrease of nasal resistances (0.048). The comparison with non-treated allergic patients shows significant differences (p = 0.02). In addition, the percentages of reversibility were associated with IL-10 levels (p = 0.0016). Conclusions: This study provides the first evidence of an association between improved nasal resistances and Treg-induced IL-10 production after sublingual immunotherapy in patients with perennial allergic rhinitis.

KW - Allergic rhinitis

KW - IL-10

KW - Nasal airflow resistance

KW - Nasal obstruction

KW - Rhinomanometry

KW - Sublingual immunotherapy

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