Sublingual immunotherapy-induced IL-10 production is associated with changed response to the decongestion test: Preliminary results

Giorgio Ciprandi, Ignazio Cirillo, Maria Angela Tosca, Gianluigi Marseglia, Daniela Fenoglio

Research output: Contribution to journalArticle

Abstract

Sublingual immunotherapy (SLIT) has been shown to be capable of inducing a regulatory T-cell response as evidenced by IL-10 production. Decongestion testing consists of spraying an intranasal vasoconstrictor drug to evaluate the recovery of nasal airflow limitation. The aim of this study was to assess the association of SLIT-induced IL-10 production with nasal airflow recovery after decongestion testing. Nineteen patients with perennial allergic rhinitis (PAR) were studied: 9 patients successfully assumed SLIT for 3 years and 10 patients were considered as control. In vitro IL-10 production was evaluated after SLIT. Rhinomanometry and decongestion testing were performed in all subjects before and after 3 years. After 3 years, SLIT patients showed a significant decrease of nasal resistances (0.048) and reduced response to decongestion testing (p = 0.044 for absolute values and p = 0.0051 for Δ). The comparison with nontreated allergic patients shows significant differences concerning both pretest values (p = 0.02) and Δ percentages (p = 0.00466). In addition, the decrease of nasal airflow resistance values and the percentages of reversibility were significantly associated with IL-10 levels (p = 0.0016 and p = 0.00294, respectively). This preliminary study provides the first evidence of a changed response to decongestion testing after SLIT that is associated with IL-10 production in patients with PAR.

Original languageEnglish
Pages (from-to)574-577
Number of pages4
JournalAllergy and Asthma Proceedings
Volume28
Issue number5
Publication statusPublished - Sep 2007

Keywords

  • Allergic rhinitis
  • Decongestion test
  • Dust mite
  • IL-10
  • Nasal airflow resistance
  • Rhinomanometry
  • SLIT
  • Sublingual immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy

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