TY - JOUR
T1 - Sublingual immunotherapy may affect serum neopterin
T2 - Preliminary findings
AU - Ciprandi, Giorgio
AU - De Amici, Mara
AU - Marseglia, Gianluigi
AU - Fuchs, Dietmar
PY - 2010/11
Y1 - 2010/11
N2 - Background: Neopterin is a protein produced by monocytes/macrophages. It has been considered a biomarker of immune activation in several disorders. However, there are few studies in allergic rhinitis (AR).This study evaluated the serum neopterin levels in patients with pollen-induced AR or treated with sublingual immunotherapy (SLIT) and in healthy subjects. Methods: 146 subjects (70 males, median age 30.5. years): 56 with moderate-severe persistent AR, 40 with AR and successfully treated with 2. year SLIT, and 50 healthy controls were consecutively evaluated outside the pollen season. A skin prick test and blood sampling for assessing serum neopterin levels were performed in all subjects. Results: SLIT-treated patients had lower neopterin levels than untreated patients and healthy subjects (respectively p = 0.012 and p = 0.0001). Conclusions: Neopterin is a biomarker for immune activation, SLIT may affect serum neopterin probably as a consequence of Treg response to SLIT.
AB - Background: Neopterin is a protein produced by monocytes/macrophages. It has been considered a biomarker of immune activation in several disorders. However, there are few studies in allergic rhinitis (AR).This study evaluated the serum neopterin levels in patients with pollen-induced AR or treated with sublingual immunotherapy (SLIT) and in healthy subjects. Methods: 146 subjects (70 males, median age 30.5. years): 56 with moderate-severe persistent AR, 40 with AR and successfully treated with 2. year SLIT, and 50 healthy controls were consecutively evaluated outside the pollen season. A skin prick test and blood sampling for assessing serum neopterin levels were performed in all subjects. Results: SLIT-treated patients had lower neopterin levels than untreated patients and healthy subjects (respectively p = 0.012 and p = 0.0001). Conclusions: Neopterin is a biomarker for immune activation, SLIT may affect serum neopterin probably as a consequence of Treg response to SLIT.
KW - Allergic rhinitis
KW - Neopterin
KW - Serum
KW - Sublingual immunotherapy
UR - http://www.scopus.com/inward/record.url?scp=77958154454&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77958154454&partnerID=8YFLogxK
U2 - 10.1016/j.intimp.2010.08.021
DO - 10.1016/j.intimp.2010.08.021
M3 - Article
C2 - 20863918
AN - SCOPUS:77958154454
VL - 10
SP - 1474
EP - 1476
JO - International Immunopharmacology
JF - International Immunopharmacology
SN - 1567-5769
IS - 11
ER -