Sublingual immunotherapy may affect serum neopterin: Preliminary findings

Giorgio Ciprandi, Mara De Amici, Gianluigi Marseglia, Dietmar Fuchs

Research output: Contribution to journalArticlepeer-review


Background: Neopterin is a protein produced by monocytes/macrophages. It has been considered a biomarker of immune activation in several disorders. However, there are few studies in allergic rhinitis (AR).This study evaluated the serum neopterin levels in patients with pollen-induced AR or treated with sublingual immunotherapy (SLIT) and in healthy subjects. Methods: 146 subjects (70 males, median age 30.5. years): 56 with moderate-severe persistent AR, 40 with AR and successfully treated with 2. year SLIT, and 50 healthy controls were consecutively evaluated outside the pollen season. A skin prick test and blood sampling for assessing serum neopterin levels were performed in all subjects. Results: SLIT-treated patients had lower neopterin levels than untreated patients and healthy subjects (respectively p = 0.012 and p = 0.0001). Conclusions: Neopterin is a biomarker for immune activation, SLIT may affect serum neopterin probably as a consequence of Treg response to SLIT.

Original languageEnglish
Pages (from-to)1474-1476
Number of pages3
JournalInternational Immunopharmacology
Issue number11
Publication statusPublished - Nov 2010


  • Allergic rhinitis
  • Neopterin
  • Serum
  • Sublingual immunotherapy

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology


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