Abstract
Allergic rhinitis (AR) is characterized by Th2 polarized immune response. Allergen-specific subcutaneous immunotherapy: may restore a physiologic Th1 profile. However, there are few studies investigating the immunological effects of sublingual immunotherapy (SLIT). The aim of this study is to investigate whether a pre-seasonal SLIT course could affect IFN-γ production. Forty-four AR patients with pollen allergy assumed pre-seasonal SLIT for 3 months. IFN-γ-specific producing cells were assessed by cytokine ELISPOT before and 3 months after the beginning of SLIT. Visual analogue scale (VAS) for symptoms and medication score was also evaluated. The frequency of IFN-γ-specific producing cells significantly increased after SLIT (p
Original language | English |
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Pages (from-to) | 169-173 |
Number of pages | 5 |
Journal | Journal of Biological Regulators and Homeostatic Agents |
Volume | 22 |
Issue number | 3 |
Publication status | Published - Jul 2008 |
Keywords
- Early marker of response
- ELISPOT
- IFN-γ production
- Sublingual immunotherapy
- Th1 cells
ASJC Scopus subject areas
- Oncology
- Endocrinology, Diabetes and Metabolism
- Physiology (medical)
- Immunology and Allergy
- Immunology
- Endocrinology
- Physiology
- Cancer Research