Sublingual immunotherapy provides an early increase of interferon-gamma production

Giorgio Ciprandi; D. Fenoglio; M. Di Gioacchino; A. Ferrera; F. Ferrera; M. P. Sormani; G. L. Marseglia

Sublingual immunotherapy provides an early increase of interferon-gamma production

Giorgio Ciprandi, D. Fenoglio, M. Di Gioacchino, A. Ferrera, F. Ferrera, M. P. Sormani, G. L. Marseglia

Research output: Contribution to journal › Article › peer-review

Abstract

Allergic rhinitis (AR) is characterized by Th2 polarized immune response. Allergen-specific subcutaneous immunotherapy: may restore a physiologic Th1 profile. However, there are few studies investigating the immunological effects of sublingual immunotherapy (SLIT). The aim of this study is to investigate whether a pre-seasonal SLIT course could affect IFN-γ production. Forty-four AR patients with pollen allergy assumed pre-seasonal SLIT for 3 months. IFN-γ-specific producing cells were assessed by cytokine ELISPOT before and 3 months after the beginning of SLIT. Visual analogue scale (VAS) for symptoms and medication score was also evaluated. The frequency of IFN-γ-specific producing cells significantly increased after SLIT (p

Original language	English
Pages (from-to)	169-173
Number of pages	5
Journal	Journal of Biological Regulators and Homeostatic Agents
Volume	22
Issue number	3
Publication status	Published - Jul 2008

Keywords

Early marker of response
ELISPOT
IFN-γ production
Sublingual immunotherapy
Th1 cells

ASJC Scopus subject areas

Oncology
Endocrinology, Diabetes and Metabolism
Physiology (medical)
Immunology and Allergy
Immunology
Endocrinology
Physiology
Cancer Research

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AU - Fenoglio, D.

AU - Di Gioacchino, M.

AU - Ferrera, A.

AU - Ferrera, F.

AU - Sormani, M. P.

AU - Marseglia, G. L.

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