Sublingual immunotherapy provides an early increase of interferon-gamma production

Giorgio Ciprandi, D. Fenoglio, M. Di Gioacchino, A. Ferrera, F. Ferrera, M. P. Sormani, G. L. Marseglia

Research output: Contribution to journalArticlepeer-review


Allergic rhinitis (AR) is characterized by Th2 polarized immune response. Allergen-specific subcutaneous immunotherapy: may restore a physiologic Th1 profile. However, there are few studies investigating the immunological effects of sublingual immunotherapy (SLIT). The aim of this study is to investigate whether a pre-seasonal SLIT course could affect IFN-γ production. Forty-four AR patients with pollen allergy assumed pre-seasonal SLIT for 3 months. IFN-γ-specific producing cells were assessed by cytokine ELISPOT before and 3 months after the beginning of SLIT. Visual analogue scale (VAS) for symptoms and medication score was also evaluated. The frequency of IFN-γ-specific producing cells significantly increased after SLIT (p

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number3
Publication statusPublished - Jul 2008


  • Early marker of response
  • IFN-γ production
  • Sublingual immunotherapy
  • Th1 cells

ASJC Scopus subject areas

  • Oncology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Immunology and Allergy
  • Immunology
  • Endocrinology
  • Physiology
  • Cancer Research


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