Abstract
Background: Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy. Objective: The aim of this study was to evaluate T cell proliferation in subjects successfully treated with SLIT for HDM. Methods: PBMCs were isolated from patients after at least 3 years of successful HDM SLIT and from matched untreated allergic and healthy control subjects. After 3 and 6 days of in vitro stimulation with PHA, Candida albicans, Dermatophagoides farinae, grasses, Parietaria judaica, and cat, proliferation. Results: Subjects treated with SLIT showed significant reduction of proliferation induced by Candida albicans, Parietaria, and grasses in comparison with untreated atopics (p=0.0002, 0.0033, and 0.009 respectively). Conclusion: This pilot study confirms reduced T cell proliferation in allergic subjects treated with SLIT.
Original language | English |
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Pages (from-to) | 147-151 |
Number of pages | 5 |
Journal | European Annals of Allergy and Clinical Immunology |
Volume | 37 |
Issue number | 4 |
Publication status | Published - Apr 2005 |
Keywords
- Immunologic tolerance
- Sublingual immunotherapy
- T cell proliferation
ASJC Scopus subject areas
- Immunology and Allergy