Sublingual specific immunotherapy reduces PBMC proliferations

D. Fenoglio, F. Puppo, I. Cirillo, A. Vizzaccaro, A. Ferrera, M. A. Tosca, G. Marseglia, G. Ciprandi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy. Objective: The aim of this study was to evaluate T cell proliferation in subjects successfully treated with SLIT for HDM. Methods: PBMCs were isolated from patients after at least 3 years of successful HDM SLIT and from matched untreated allergic and healthy control subjects. After 3 and 6 days of in vitro stimulation with PHA, Candida albicans, Dermatophagoides farinae, grasses, Parietaria judaica, and cat, proliferation. Results: Subjects treated with SLIT showed significant reduction of proliferation induced by Candida albicans, Parietaria, and grasses in comparison with untreated atopics (p=0.0002, 0.0033, and 0.009 respectively). Conclusion: This pilot study confirms reduced T cell proliferation in allergic subjects treated with SLIT.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalEuropean Annals of Allergy and Clinical Immunology
Volume37
Issue number4
Publication statusPublished - Apr 2005

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Parietaria
Sublingual Immunotherapy
Poaceae
Candida albicans
Cell Proliferation
Dermatophagoides farinae
T-Lymphocytes
Immunotherapy
Healthy Volunteers
Cats

Keywords

  • Immunologic tolerance
  • Sublingual immunotherapy
  • T cell proliferation

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Fenoglio, D., Puppo, F., Cirillo, I., Vizzaccaro, A., Ferrera, A., Tosca, M. A., ... Ciprandi, G. (2005). Sublingual specific immunotherapy reduces PBMC proliferations. European Annals of Allergy and Clinical Immunology, 37(4), 147-151.

Sublingual specific immunotherapy reduces PBMC proliferations. / Fenoglio, D.; Puppo, F.; Cirillo, I.; Vizzaccaro, A.; Ferrera, A.; Tosca, M. A.; Marseglia, G.; Ciprandi, G.

In: European Annals of Allergy and Clinical Immunology, Vol. 37, No. 4, 04.2005, p. 147-151.

Research output: Contribution to journalArticle

Fenoglio, D, Puppo, F, Cirillo, I, Vizzaccaro, A, Ferrera, A, Tosca, MA, Marseglia, G & Ciprandi, G 2005, 'Sublingual specific immunotherapy reduces PBMC proliferations', European Annals of Allergy and Clinical Immunology, vol. 37, no. 4, pp. 147-151.
Fenoglio, D. ; Puppo, F. ; Cirillo, I. ; Vizzaccaro, A. ; Ferrera, A. ; Tosca, M. A. ; Marseglia, G. ; Ciprandi, G. / Sublingual specific immunotherapy reduces PBMC proliferations. In: European Annals of Allergy and Clinical Immunology. 2005 ; Vol. 37, No. 4. pp. 147-151.
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AU - Marseglia, G.

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AB - Background: Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy. Objective: The aim of this study was to evaluate T cell proliferation in subjects successfully treated with SLIT for HDM. Methods: PBMCs were isolated from patients after at least 3 years of successful HDM SLIT and from matched untreated allergic and healthy control subjects. After 3 and 6 days of in vitro stimulation with PHA, Candida albicans, Dermatophagoides farinae, grasses, Parietaria judaica, and cat, proliferation. Results: Subjects treated with SLIT showed significant reduction of proliferation induced by Candida albicans, Parietaria, and grasses in comparison with untreated atopics (p=0.0002, 0.0033, and 0.009 respectively). Conclusion: This pilot study confirms reduced T cell proliferation in allergic subjects treated with SLIT.

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