Abstract
Background: Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy. Objective: The aim of this study was to evaluate T cell proliferation in subjects successfully treated with SLIT for HDM. Methods: PBMCs were isolated from patients after at least 3 years of successful HDM SLIT and from matched untreated allergic and healthy control subjects. After 3 and 6 days of in vitro stimulation with PHA, Candida albicans, Dermatophagoides farinae, grasses, Parietaria judaica, and cat, proliferation. Results: Subjects treated with SLIT showed significant reduction of proliferation induced by Candida albicans, Parietaria, and grasses in comparison with untreated atopics (p=0.0002, 0.0033, and 0.009 respectively). Conclusion: This pilot study confirms reduced T cell proliferation in allergic subjects treated with SLIT.
| Original language | English |
|---|---|
| Pages (from-to) | 147-151 |
| Number of pages | 5 |
| Journal | European Annals of Allergy and Clinical Immunology |
| Volume | 37 |
| Issue number | 4 |
| Publication status | Published - Apr 2005 |
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Keywords
- Immunologic tolerance
- Sublingual immunotherapy
- T cell proliferation
ASJC Scopus subject areas
- Immunology and Allergy
Cite this
Sublingual specific immunotherapy reduces PBMC proliferations. / Fenoglio, D.; Puppo, F.; Cirillo, I.; Vizzaccaro, A.; Ferrera, A.; Tosca, M. A.; Marseglia, G.; Ciprandi, G.
In: European Annals of Allergy and Clinical Immunology, Vol. 37, No. 4, 04.2005, p. 147-151.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sublingual specific immunotherapy reduces PBMC proliferations
AU - Fenoglio, D.
AU - Puppo, F.
AU - Cirillo, I.
AU - Vizzaccaro, A.
AU - Ferrera, A.
AU - Tosca, M. A.
AU - Marseglia, G.
AU - Ciprandi, G.
PY - 2005/4
Y1 - 2005/4
N2 - Background: Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy. Objective: The aim of this study was to evaluate T cell proliferation in subjects successfully treated with SLIT for HDM. Methods: PBMCs were isolated from patients after at least 3 years of successful HDM SLIT and from matched untreated allergic and healthy control subjects. After 3 and 6 days of in vitro stimulation with PHA, Candida albicans, Dermatophagoides farinae, grasses, Parietaria judaica, and cat, proliferation. Results: Subjects treated with SLIT showed significant reduction of proliferation induced by Candida albicans, Parietaria, and grasses in comparison with untreated atopics (p=0.0002, 0.0033, and 0.009 respectively). Conclusion: This pilot study confirms reduced T cell proliferation in allergic subjects treated with SLIT.
AB - Background: Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy. Objective: The aim of this study was to evaluate T cell proliferation in subjects successfully treated with SLIT for HDM. Methods: PBMCs were isolated from patients after at least 3 years of successful HDM SLIT and from matched untreated allergic and healthy control subjects. After 3 and 6 days of in vitro stimulation with PHA, Candida albicans, Dermatophagoides farinae, grasses, Parietaria judaica, and cat, proliferation. Results: Subjects treated with SLIT showed significant reduction of proliferation induced by Candida albicans, Parietaria, and grasses in comparison with untreated atopics (p=0.0002, 0.0033, and 0.009 respectively). Conclusion: This pilot study confirms reduced T cell proliferation in allergic subjects treated with SLIT.
KW - Immunologic tolerance
KW - Sublingual immunotherapy
KW - T cell proliferation
UR - http://www.scopus.com/inward/record.url?scp=18744401056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18744401056&partnerID=8YFLogxK
M3 - Article
C2 - 15916016
AN - SCOPUS:18744401056
VL - 37
SP - 147
EP - 151
JO - Allergie et Immunologie
JF - Allergie et Immunologie
SN - 0397-9148
IS - 4
ER -