Sublingual specific immunotherapy reduces PBMC proliferations

D. Fenoglio; F. Puppo; I. Cirillo; A. Vizzaccaro; A. Ferrera; M. A. Tosca; G. Marseglia; G. Ciprandi

Sublingual specific immunotherapy reduces PBMC proliferations

D. Fenoglio, F. Puppo, I. Cirillo, A. Vizzaccaro, A. Ferrera, M. A. Tosca, G. Marseglia, G. Ciprandi

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy. Objective: The aim of this study was to evaluate T cell proliferation in subjects successfully treated with SLIT for HDM. Methods: PBMCs were isolated from patients after at least 3 years of successful HDM SLIT and from matched untreated allergic and healthy control subjects. After 3 and 6 days of in vitro stimulation with PHA, Candida albicans, Dermatophagoides farinae, grasses, Parietaria judaica, and cat, proliferation. Results: Subjects treated with SLIT showed significant reduction of proliferation induced by Candida albicans, Parietaria, and grasses in comparison with untreated atopics (p=0.0002, 0.0033, and 0.009 respectively). Conclusion: This pilot study confirms reduced T cell proliferation in allergic subjects treated with SLIT.

Original language	English
Pages (from-to)	147-151
Number of pages	5
Journal	European Annals of Allergy and Clinical Immunology
Volume	37
Issue number	4
Publication status	Published - Apr 2005

Keywords

Immunologic tolerance
Sublingual immunotherapy
T cell proliferation

ASJC Scopus subject areas

Immunology and Allergy

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@article{5a550d8fbf084c17be9cfd5c534dd951,

title = "Sublingual specific immunotherapy reduces PBMC proliferations",

abstract = "Background: Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy. Objective: The aim of this study was to evaluate T cell proliferation in subjects successfully treated with SLIT for HDM. Methods: PBMCs were isolated from patients after at least 3 years of successful HDM SLIT and from matched untreated allergic and healthy control subjects. After 3 and 6 days of in vitro stimulation with PHA, Candida albicans, Dermatophagoides farinae, grasses, Parietaria judaica, and cat, proliferation. Results: Subjects treated with SLIT showed significant reduction of proliferation induced by Candida albicans, Parietaria, and grasses in comparison with untreated atopics (p=0.0002, 0.0033, and 0.009 respectively). Conclusion: This pilot study confirms reduced T cell proliferation in allergic subjects treated with SLIT.",

keywords = "Immunologic tolerance, Sublingual immunotherapy, T cell proliferation",

author = "D. Fenoglio and F. Puppo and I. Cirillo and A. Vizzaccaro and A. Ferrera and Tosca, {M. A.} and G. Marseglia and G. Ciprandi",

year = "2005",

month = apr,

language = "English",

volume = "37",

pages = "147--151",

journal = "Allergie et Immunologie",

issn = "0397-9148",

publisher = "Mattioli 1885 S.p.A.",

number = "4",

}

TY - JOUR

T1 - Sublingual specific immunotherapy reduces PBMC proliferations

AU - Fenoglio, D.

AU - Puppo, F.

AU - Cirillo, I.

AU - Vizzaccaro, A.

AU - Ferrera, A.

AU - Tosca, M. A.

AU - Marseglia, G.

AU - Ciprandi, G.

PY - 2005/4

Y1 - 2005/4

N2 - Background: Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy. Objective: The aim of this study was to evaluate T cell proliferation in subjects successfully treated with SLIT for HDM. Methods: PBMCs were isolated from patients after at least 3 years of successful HDM SLIT and from matched untreated allergic and healthy control subjects. After 3 and 6 days of in vitro stimulation with PHA, Candida albicans, Dermatophagoides farinae, grasses, Parietaria judaica, and cat, proliferation. Results: Subjects treated with SLIT showed significant reduction of proliferation induced by Candida albicans, Parietaria, and grasses in comparison with untreated atopics (p=0.0002, 0.0033, and 0.009 respectively). Conclusion: This pilot study confirms reduced T cell proliferation in allergic subjects treated with SLIT.

AB - Background: Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy. Objective: The aim of this study was to evaluate T cell proliferation in subjects successfully treated with SLIT for HDM. Methods: PBMCs were isolated from patients after at least 3 years of successful HDM SLIT and from matched untreated allergic and healthy control subjects. After 3 and 6 days of in vitro stimulation with PHA, Candida albicans, Dermatophagoides farinae, grasses, Parietaria judaica, and cat, proliferation. Results: Subjects treated with SLIT showed significant reduction of proliferation induced by Candida albicans, Parietaria, and grasses in comparison with untreated atopics (p=0.0002, 0.0033, and 0.009 respectively). Conclusion: This pilot study confirms reduced T cell proliferation in allergic subjects treated with SLIT.

KW - Immunologic tolerance

KW - Sublingual immunotherapy

KW - T cell proliferation

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JO - Allergie et Immunologie

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