Suboptimal stent deployment is associated with subacute stent thrombosis: Optical coherence tomography insights from a multicenter matched study. From the CLI Foundation investigators: The CLI-THRO study

Francesco Prati, Takahide Kodama, Enrico Romagnoli, Laura Gatto, Luca Di Vito, Vito Ramazzotti, Alberto Chisari, Valeria Marco, Alberto Cremonesi, Guido Parodi, Mario Albertucci, Fernando Alfonso

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Abstract

Background Acute or subacute stent thrombosis (ST) is a well-described complication usually causing acute coronary syndromes and, in the worst case scenario, sudden cardiac death. In this study, we aimed at exploring the potential role of optical coherence tomography (OCT) in the understanding of the mechanism of ST. Methods Twenty-one consecutive patients, after acute coronary syndromes due to a definite subacute ST, were assessed with OCT and matched 1:2 with 42 patients undergoing OCT for scheduled follow-up. Optical coherence tomography assessment was focused on features indicative of nonoptimal stent deployment: underexpansion, malapposition, edge dissection, and reference lumen narrowing. Results Optical coherence tomography revealed a minimum stent area sensibly smaller in the ST group (5.6 ± 2.6 vs 6.8 ± 1.7 mm2; P =.03) with a higher incidence of stent underexpansion when compared with the control group (42.8% vs 16.7%; P =.05). Dissection at stent edges was more commonly detected in ST group (52.4% vs 9.5%; P

Original languageEnglish
Pages (from-to)249-256
Number of pages8
JournalAmerican Heart Journal
Volume169
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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    Prati, F., Kodama, T., Romagnoli, E., Gatto, L., Di Vito, L., Ramazzotti, V., Chisari, A., Marco, V., Cremonesi, A., Parodi, G., Albertucci, M., & Alfonso, F. (2015). Suboptimal stent deployment is associated with subacute stent thrombosis: Optical coherence tomography insights from a multicenter matched study. From the CLI Foundation investigators: The CLI-THRO study. American Heart Journal, 169(2), 249-256. https://doi.org/10.1016/j.ahj.2014.11.012