Suboptimal use of neoadjuvant chemotherapy in radical cystectomy patients: A population-based study

Jonas Schiffmann, Maxine Sun, Giorgio Gandaglia, Zhe Tian, Ioana Popa, Alessandro Larcher, Malek Meskawi, Alberto Briganti, Michael McCormack, Shahrokh F. Shariat, Francesco Montorsi, Markus Graefen, Fred Saad, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: We aimed to assess contemporary rates of neoadjuvant chemotherapy (NC) use. Methods: We relied on the Surveillance, Epidemiology and End Results (SEER)-Medicare database for non-metastatic, muscle-invasive (T2-T4a) urothelial carcinoma of the urinary bladder (UCUB) patients who underwent radical cystectomy (RC) between 1991 and 2009. Multivariable logistic regression analyses tested predictors of NC use, such as: T-stage, N-stage, year of diagnosis, age at diagnosis, gender, race, use of radiotherapy (RT), marital status, urban status, socioeconomic status, tumour grade, and Charlson comorbidity index (CCI). Results: Overall, 5207 patients treated with RC were identified. Of those, 332 (6.4%) received NC. The rate of NC increased over time from 6.1% (1991) to 15.0% (2009) (p

Original languageEnglish
Pages (from-to)E82-E86
JournalCanadian Urological Association Journal
Volume10
Issue number3-4
DOIs
Publication statusPublished - Mar 1 2016

ASJC Scopus subject areas

  • Urology
  • Oncology

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