Subretinal Hyperreflective Material Imaged With Optical Coherence Tomography Angiography

Kunal K. Dansingani, Anna C.S. Tan, Fatimah Gilani, Nopasak Phasukkijwatana, Eduardo Novais, Lea Querques, Nadia K. Waheed, Jay S. Duker, Giuseppe Querques, Lawrence A. Yannuzzi, David Sarraf, K. Bailey Freund

Research output: Contribution to journalArticle

Abstract

Purpose The range of subretinal hyperreflective material (SHRM) seen in macular disease includes type 2 macular neovascularization, fibrosis, exudation, vitelliform material, and hemorrhage. The prognostic significance of SHRM has been evaluated retrospectively in clinical trials, but discriminating SHRM subtypes traditionally requires multiple imaging modalities. The purpose of this study is to describe optical coherence tomography angiography (OCTA) flow characteristics and artifacts that might help to distinguish SHRM subtypes. Design Validity analysis. Methods Patients with age-related macular degeneration (AMD), myopia, pachychoroid disease, and macular dystrophy, manifesting SHRM on optical coherence tomography (OCT), were recruited. Clinical chart review and multimodal imaging established the SHRM subtype. All patients underwent OCTA. OCT and OCTA images were examined together for (1) intrinsic flow, (2) retinal projection onto the anterior SHRM surface (strong, weak, absent), (3) retinal projection through SHRM onto retinal pigment epithelium (RPE), and (4) masking of choriocapillaris flow. Results Thirty-three eyes of 25 patients were included (type 2 neovascularization ×3; fibrosis ×4; exudation ×10; hemorrhage ×5; vitelliform ×17). Mean age per eye was 76 years (standard deviation: 12). Intrinsic flow was strongest in type 2 neovascularization. Subretinal fibrosis showed limited flow in residual large-caliber vessels and branches. Flow was not detected within foci of exudation, hemorrhage, or vitelliform lesions. Retina-SHRM surface projection was strongest onto smooth-surfaced SHRM and weaker onto exudation. Retinal projection was weakest on the surface of vitelliform lesions. Retina-RPE projection was masked by dense hemorrhage and vitelliform material. In compound SHRM, OCTA distinguished between vascular and avascular components. Conclusion Optical coherence tomography angiography can distinguish vascular from avascular SHRM components. OCTA artifacts may distinguish certain avascular SHRM components.
Original languageEnglish
Pages (from-to)235 - 248
Number of pages14
JournalAmerican Journal of Ophthalmology
Volume169
DOIs
Publication statusPublished - Sep 1 2016

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Optical Coherence Tomography
Angiography
Hemorrhage
Fibrosis
Retinal Pigment Epithelium
Macular Degeneration
Artifacts
Blood Vessels
Retina
Multimodal Imaging
Myopia
Clinical Trials

ASJC Scopus subject areas

  • Medicine(all)
  • Ophthalmology

Cite this

Dansingani, K. K., Tan, A. C. S., Gilani, F., Phasukkijwatana, N., Novais, E., Querques, L., ... Freund, K. B. (2016). Subretinal Hyperreflective Material Imaged With Optical Coherence Tomography Angiography. American Journal of Ophthalmology, 169, 235 - 248. https://doi.org/10.1016/j.ajo.2016.06.031

Subretinal Hyperreflective Material Imaged With Optical Coherence Tomography Angiography. / Dansingani, Kunal K.; Tan, Anna C.S.; Gilani, Fatimah; Phasukkijwatana, Nopasak; Novais, Eduardo; Querques, Lea; Waheed, Nadia K.; Duker, Jay S.; Querques, Giuseppe; Yannuzzi, Lawrence A.; Sarraf, David; Freund, K. Bailey.

In: American Journal of Ophthalmology, Vol. 169, 01.09.2016, p. 235 - 248.

Research output: Contribution to journalArticle

Dansingani, KK, Tan, ACS, Gilani, F, Phasukkijwatana, N, Novais, E, Querques, L, Waheed, NK, Duker, JS, Querques, G, Yannuzzi, LA, Sarraf, D & Freund, KB 2016, 'Subretinal Hyperreflective Material Imaged With Optical Coherence Tomography Angiography', American Journal of Ophthalmology, vol. 169, pp. 235 - 248. https://doi.org/10.1016/j.ajo.2016.06.031
Dansingani KK, Tan ACS, Gilani F, Phasukkijwatana N, Novais E, Querques L et al. Subretinal Hyperreflective Material Imaged With Optical Coherence Tomography Angiography. American Journal of Ophthalmology. 2016 Sep 1;169:235 - 248. https://doi.org/10.1016/j.ajo.2016.06.031
Dansingani, Kunal K. ; Tan, Anna C.S. ; Gilani, Fatimah ; Phasukkijwatana, Nopasak ; Novais, Eduardo ; Querques, Lea ; Waheed, Nadia K. ; Duker, Jay S. ; Querques, Giuseppe ; Yannuzzi, Lawrence A. ; Sarraf, David ; Freund, K. Bailey. / Subretinal Hyperreflective Material Imaged With Optical Coherence Tomography Angiography. In: American Journal of Ophthalmology. 2016 ; Vol. 169. pp. 235 - 248.
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AU - Novais, Eduardo

AU - Querques, Lea

AU - Waheed, Nadia K.

AU - Duker, Jay S.

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