Substance P-like immunoreactivity at the frog neuromuscular junction

M. Matteoli, C. Haimann, P. De Camilli

Research output: Contribution to journalArticlepeer-review


It has been recently shown that frog motoneurons and their nerve terminals contain calcitonin gene-related peptide-like immunoreactivity in large dense-core vesicles (Matteoli et al., Proc. natn. Acad. Sci. U.S.A. 85, 7366-7370, 1988). We report here by an immunofluorescence approach that the same neurons and nerve terminals also contain substance P-like immunoreactivity. The demonstration of substance P-like immunoreactivity in the frog motor nerve endings supports previous data suggesting a physiological role for this peptide in the modulation of cholinergic transmission.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
Issue number1
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Neuroscience(all)


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