Abstract
This study focused on the substantia nigra (SN) in Parkinson's disease (PD). We measured its area and volume, mean diffusivity (MD), fractional anisotropy (FA) and iron concentration in early and late PD and correlated the values with clinical scores. Twenty-two early PD (EPD), 20 late PD (LPD) and 20 healthy subjects (age 64.7 ± 4.9, 60.5 ± 6.1, and 61 ± 7.2 years, respectively) underwent 1.5 T MR imaging with double-TI-IR T1-weighted, T2*-weighted and diffusion tensor imaging scans. Relative SN area, MD, FA and R2* were measured in ROIs traced on SN. Correlation with Unified Parkinson Disease Rating Scale (UPDRS) scores was assessed. In LPD, the SN area was significantly reduced with respect to EPD (p = 0.04) and control subjects (p <0.001). In EPD, the SN area was also significantly smaller than in controls (p = 0.006). Similarly, the SN volume significantly differed between LPD and controls (p = 0.001) and between EPD and LPD (p = 0.049), while no significant differences were found between controls and EPD. Both SN area (r = 0.47, p = 0.004) and volume (r = 0.46, p = 0.005) correlated with UPDRS scores. At 1.5 T, SN morphological measurements were sensitive to early PD changes and able to track the disease progression, while MD and FA measures and relaxometry did not provide significant results.
| Original language | English |
|---|---|
| Pages (from-to) | 753-758 |
| Number of pages | 6 |
| Journal | Neurological Sciences |
| Volume | 35 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Diffusion tensor imaging
- Inversion recovery
- Parkinson disease
- Relaxometry
- Substantia nigra
- UPDRS
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
- Medicine(all)
Cite this
Substantia nigra in Parkinson's disease : A multimodal MRI comparison between early and advanced stages of the disease. / Aquino, Domenico; Contarino, Valeria; Albanese, Alberto; Minati, Ludovico; Farina, Laura; Grisoli, Marina; Elia, Antonio; Bruzzone, Maria Grazia; Chiapparini, Luisa.
In: Neurological Sciences, Vol. 35, No. 5, 2014, p. 753-758.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Substantia nigra in Parkinson's disease
T2 - A multimodal MRI comparison between early and advanced stages of the disease
AU - Aquino, Domenico
AU - Contarino, Valeria
AU - Albanese, Alberto
AU - Minati, Ludovico
AU - Farina, Laura
AU - Grisoli, Marina
AU - Elia, Antonio
AU - Bruzzone, Maria Grazia
AU - Chiapparini, Luisa
PY - 2014
Y1 - 2014
N2 - This study focused on the substantia nigra (SN) in Parkinson's disease (PD). We measured its area and volume, mean diffusivity (MD), fractional anisotropy (FA) and iron concentration in early and late PD and correlated the values with clinical scores. Twenty-two early PD (EPD), 20 late PD (LPD) and 20 healthy subjects (age 64.7 ± 4.9, 60.5 ± 6.1, and 61 ± 7.2 years, respectively) underwent 1.5 T MR imaging with double-TI-IR T1-weighted, T2*-weighted and diffusion tensor imaging scans. Relative SN area, MD, FA and R2* were measured in ROIs traced on SN. Correlation with Unified Parkinson Disease Rating Scale (UPDRS) scores was assessed. In LPD, the SN area was significantly reduced with respect to EPD (p = 0.04) and control subjects (p <0.001). In EPD, the SN area was also significantly smaller than in controls (p = 0.006). Similarly, the SN volume significantly differed between LPD and controls (p = 0.001) and between EPD and LPD (p = 0.049), while no significant differences were found between controls and EPD. Both SN area (r = 0.47, p = 0.004) and volume (r = 0.46, p = 0.005) correlated with UPDRS scores. At 1.5 T, SN morphological measurements were sensitive to early PD changes and able to track the disease progression, while MD and FA measures and relaxometry did not provide significant results.
AB - This study focused on the substantia nigra (SN) in Parkinson's disease (PD). We measured its area and volume, mean diffusivity (MD), fractional anisotropy (FA) and iron concentration in early and late PD and correlated the values with clinical scores. Twenty-two early PD (EPD), 20 late PD (LPD) and 20 healthy subjects (age 64.7 ± 4.9, 60.5 ± 6.1, and 61 ± 7.2 years, respectively) underwent 1.5 T MR imaging with double-TI-IR T1-weighted, T2*-weighted and diffusion tensor imaging scans. Relative SN area, MD, FA and R2* were measured in ROIs traced on SN. Correlation with Unified Parkinson Disease Rating Scale (UPDRS) scores was assessed. In LPD, the SN area was significantly reduced with respect to EPD (p = 0.04) and control subjects (p <0.001). In EPD, the SN area was also significantly smaller than in controls (p = 0.006). Similarly, the SN volume significantly differed between LPD and controls (p = 0.001) and between EPD and LPD (p = 0.049), while no significant differences were found between controls and EPD. Both SN area (r = 0.47, p = 0.004) and volume (r = 0.46, p = 0.005) correlated with UPDRS scores. At 1.5 T, SN morphological measurements were sensitive to early PD changes and able to track the disease progression, while MD and FA measures and relaxometry did not provide significant results.
KW - Diffusion tensor imaging
KW - Inversion recovery
KW - Parkinson disease
KW - Relaxometry
KW - Substantia nigra
KW - UPDRS
UR - http://www.scopus.com/inward/record.url?scp=84901381999&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901381999&partnerID=8YFLogxK
U2 - 10.1007/s10072-013-1595-2
DO - 10.1007/s10072-013-1595-2
M3 - Article
C2 - 24337946
AN - SCOPUS:84901381999
VL - 35
SP - 753
EP - 758
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 5
ER -