Substantial overview on mesenchymal stem cell biological and physical properties as an opportunity in translational medicine

Heba Abdelrazik, Emanuele Giordano, Giovanni Barbanti Brodano, Cristiana Griffoni, Elena De Falco, Alessandra Pelagalli

Research output: Contribution to journalReview articlepeer-review


Mesenchymal stem cells (MSC) have piqued worldwide interest for their extensive potential to treat a large array of clinical indications, their unique and controversial immunogenic and immune modulatory properties allowing ample discussions and debates for their possible applications. Emerging data demonstrating that the interaction of biomaterials and physical cues with MSC can guide their differentiation into specific cell lineages also provide new interesting insights for further MSC manipulation in different clinical applications. Moreover, recent discoveries of some regulatory molecules and signaling pathways in MSC niche that may regulate cell fate to distinct lineage herald breakthroughs in regenerative medicine. Although the advancement and success in the MSC field had led to an enormous increase in the amount of ongoing clinical trials, we still lack defined clinical therapeutic protocols. This review will explore the exciting opportunities offered by human and animal MSC, describing relevant biological properties of these cells in the light of the novel emerging evidence mentioned above while addressing the limitations and challenges MSC are still facing.

Original languageEnglish
Article number5386
JournalInternational Journal of Molecular Sciences
Issue number21
Publication statusPublished - Nov 1 2019


  • 3D scaffolds
  • Angiogenesis
  • Biomaterials
  • Bone regeneration
  • Immune modulation
  • Mesenchymal stem cells (MSC)
  • Translational medicine

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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