Abstract
From the time catheter ablation of atrial fibrillation (AF) was first reported, of the two dominant approaches for AF ablation, only pulmonary vein (PV) isolation has been modified, while circumferential pulmonary vein ablation (CPVA) as performed by our group in Milan has remained substantially unmodified. In fact, PV isolation as initially performed by Haissaguerre et al. has undergone rapid evolution toward substrate modification with significantly higher success rates without major complications. Modification of such technique was due to modification of the substrate. It is now evident that substrate modification is indeed crucial for curing AF particularly in patients with long-lasting or permanent AF. Indeed, to achieve good outcomes, any ablation technique should simultaneously include elimination of all triggers associated with modification of both anatomic and autonomic substrate, as we started to do many years ago by performing CPVA.
| Original language | English |
|---|---|
| Journal | Journal of Cardiovascular Electrophysiology |
| Volume | 17 |
| Issue number | SUPPL. 3 |
| DOIs | |
| Publication status | Published - Dec 2006 |
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Keywords
- Atrial fibrillation
- Catheter ablation
- Mapping
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology
Cite this
Substrate ablation in treatment of atrial fibrillation. / Pappone, Carlo; Santinelli, Vincenzo.
In: Journal of Cardiovascular Electrophysiology, Vol. 17, No. SUPPL. 3, 12.2006.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Substrate ablation in treatment of atrial fibrillation
AU - Pappone, Carlo
AU - Santinelli, Vincenzo
PY - 2006/12
Y1 - 2006/12
N2 - From the time catheter ablation of atrial fibrillation (AF) was first reported, of the two dominant approaches for AF ablation, only pulmonary vein (PV) isolation has been modified, while circumferential pulmonary vein ablation (CPVA) as performed by our group in Milan has remained substantially unmodified. In fact, PV isolation as initially performed by Haissaguerre et al. has undergone rapid evolution toward substrate modification with significantly higher success rates without major complications. Modification of such technique was due to modification of the substrate. It is now evident that substrate modification is indeed crucial for curing AF particularly in patients with long-lasting or permanent AF. Indeed, to achieve good outcomes, any ablation technique should simultaneously include elimination of all triggers associated with modification of both anatomic and autonomic substrate, as we started to do many years ago by performing CPVA.
AB - From the time catheter ablation of atrial fibrillation (AF) was first reported, of the two dominant approaches for AF ablation, only pulmonary vein (PV) isolation has been modified, while circumferential pulmonary vein ablation (CPVA) as performed by our group in Milan has remained substantially unmodified. In fact, PV isolation as initially performed by Haissaguerre et al. has undergone rapid evolution toward substrate modification with significantly higher success rates without major complications. Modification of such technique was due to modification of the substrate. It is now evident that substrate modification is indeed crucial for curing AF particularly in patients with long-lasting or permanent AF. Indeed, to achieve good outcomes, any ablation technique should simultaneously include elimination of all triggers associated with modification of both anatomic and autonomic substrate, as we started to do many years ago by performing CPVA.
KW - Atrial fibrillation
KW - Catheter ablation
KW - Mapping
UR - http://www.scopus.com/inward/record.url?scp=33751172099&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33751172099&partnerID=8YFLogxK
U2 - 10.1111/j.1540-8167.2006.00630.x
DO - 10.1111/j.1540-8167.2006.00630.x
M3 - Article
VL - 17
JO - Journal of Cardiovascular Electrophysiology
JF - Journal of Cardiovascular Electrophysiology
SN - 1045-3873
IS - SUPPL. 3
ER -