Subthalamic somatosensory evoked potentials in Parkinson's disease

Alessandra Pesenti, Alberto Priori, Marco Locatelli, Marcello Egidi, Paolo Rampini, Filippo Tamma, Elena Caputo, Valentina Chiesa, Sergio Barbieri

Research output: Contribution to journalArticlepeer-review

Abstract

Deep brain stimulation (DBS) of subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease. It also provides an opportunity to record neural activity from the human basal ganglia. In this study, to investigate the involvement of the human STN in sensory functions, we recorded somatosensory evoked potentials (SEPs) elicited by contralateral median-nerve stimulation, from STN electrodes implanted for DBS in patients with Parkinson's disease. We suggest that the STN N18 component of SEPs in Parkinson's disease is a mainly local field potential elicited by muscle afferent input to the nucleus.

Original languageEnglish
Pages (from-to)1341-1345
Number of pages5
JournalMovement Disorders
Volume18
Issue number11
DOIs
Publication statusPublished - Nov 2003

Keywords

  • Deep brain stimulation (DBS)
  • Evoked potentials
  • Parkinson's disease
  • Somatosensory processing
  • Subthalamic nucleus (STN)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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