Subthalamic stimulation activates internal pallidus: Evidence from cGMP microdialysis in PD patients

Alessandro Stefani, Ernesto Fedele, Salvatore Galati, Olimpia Pepicelli, Stefania Frasca, Mariangela Pierantozzi, Antonella Peppe, Livia Brusa, Antonio Orlacchio, Atticus H. Hainsworth, Giuseppe Gattoni, Paolo Stanzione, Giorgio Bernardi, Maurizio Raiteri, Paolo Mazzone

Research output: Contribution to journalArticle

Abstract

Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN-DBS. This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi.

Original languageEnglish
Pages (from-to)448-452
Number of pages5
JournalAnnals of Neurology
Volume57
Issue number3
DOIs
Publication statusPublished - Mar 2005

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Stefani, A., Fedele, E., Galati, S., Pepicelli, O., Frasca, S., Pierantozzi, M., Peppe, A., Brusa, L., Orlacchio, A., Hainsworth, A. H., Gattoni, G., Stanzione, P., Bernardi, G., Raiteri, M., & Mazzone, P. (2005). Subthalamic stimulation activates internal pallidus: Evidence from cGMP microdialysis in PD patients. Annals of Neurology, 57(3), 448-452. https://doi.org/10.1002/ana.20402