Abstract
Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN-DBS. This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi.
| Original language | English |
|---|---|
| Pages (from-to) | 448-452 |
| Number of pages | 5 |
| Journal | Annals of Neurology |
| Volume | 57 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2005 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Subthalamic stimulation activates internal pallidus : Evidence from cGMP microdialysis in PD patients. / Stefani, Alessandro; Fedele, Ernesto; Galati, Salvatore; Pepicelli, Olimpia; Frasca, Stefania; Pierantozzi, Mariangela; Peppe, Antonella; Brusa, Livia; Orlacchio, Antonio; Hainsworth, Atticus H.; Gattoni, Giuseppe; Stanzione, Paolo; Bernardi, Giorgio; Raiteri, Maurizio; Mazzone, Paolo.
In: Annals of Neurology, Vol. 57, No. 3, 03.2005, p. 448-452.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subthalamic stimulation activates internal pallidus
T2 - Evidence from cGMP microdialysis in PD patients
AU - Stefani, Alessandro
AU - Fedele, Ernesto
AU - Galati, Salvatore
AU - Pepicelli, Olimpia
AU - Frasca, Stefania
AU - Pierantozzi, Mariangela
AU - Peppe, Antonella
AU - Brusa, Livia
AU - Orlacchio, Antonio
AU - Hainsworth, Atticus H.
AU - Gattoni, Giuseppe
AU - Stanzione, Paolo
AU - Bernardi, Giorgio
AU - Raiteri, Maurizio
AU - Mazzone, Paolo
PY - 2005/3
Y1 - 2005/3
N2 - Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN-DBS. This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi.
AB - Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN-DBS. This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi.
UR - http://www.scopus.com/inward/record.url?scp=20044369699&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20044369699&partnerID=8YFLogxK
U2 - 10.1002/ana.20402
DO - 10.1002/ana.20402
M3 - Article
VL - 57
SP - 448
EP - 452
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 3
ER -