TY - JOUR
T1 - Subthalamic stimulation activates internal pallidus
T2 - Evidence from cGMP microdialysis in PD patients
AU - Stefani, Alessandro
AU - Fedele, Ernesto
AU - Galati, Salvatore
AU - Pepicelli, Olimpia
AU - Frasca, Stefania
AU - Pierantozzi, Mariangela
AU - Peppe, Antonella
AU - Brusa, Livia
AU - Orlacchio, Antonio
AU - Hainsworth, Atticus H.
AU - Gattoni, Giuseppe
AU - Stanzione, Paolo
AU - Bernardi, Giorgio
AU - Raiteri, Maurizio
AU - Mazzone, Paolo
PY - 2005/3
Y1 - 2005/3
N2 - Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN-DBS. This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi.
AB - Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN-DBS. This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi.
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U2 - 10.1002/ana.20402
DO - 10.1002/ana.20402
M3 - Article
C2 - 15732123
AN - SCOPUS:20044369699
VL - 57
SP - 448
EP - 452
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 3
ER -