Subthalamic stimulation activates internal pallidus

Evidence from cGMP microdialysis in PD patients

Alessandro Stefani, Ernesto Fedele, Salvatore Galati, Olimpia Pepicelli, Stefania Frasca, Mariangela Pierantozzi, Antonella Peppe, Livia Brusa, Antonio Orlacchio, Atticus H. Hainsworth, Giuseppe Gattoni, Paolo Stanzione, Giorgio Bernardi, Maurizio Raiteri, Paolo Mazzone

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN-DBS. This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi.

Original languageEnglish
Pages (from-to)448-452
Number of pages5
JournalAnnals of Neurology
Volume57
Issue number3
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Subthalamic Nucleus
Microdialysis
Deep Brain Stimulation
Globus Pallidus
Parkinson Disease
Glutamic Acid

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Stefani, A., Fedele, E., Galati, S., Pepicelli, O., Frasca, S., Pierantozzi, M., ... Mazzone, P. (2005). Subthalamic stimulation activates internal pallidus: Evidence from cGMP microdialysis in PD patients. Annals of Neurology, 57(3), 448-452. https://doi.org/10.1002/ana.20402

Subthalamic stimulation activates internal pallidus : Evidence from cGMP microdialysis in PD patients. / Stefani, Alessandro; Fedele, Ernesto; Galati, Salvatore; Pepicelli, Olimpia; Frasca, Stefania; Pierantozzi, Mariangela; Peppe, Antonella; Brusa, Livia; Orlacchio, Antonio; Hainsworth, Atticus H.; Gattoni, Giuseppe; Stanzione, Paolo; Bernardi, Giorgio; Raiteri, Maurizio; Mazzone, Paolo.

In: Annals of Neurology, Vol. 57, No. 3, 03.2005, p. 448-452.

Research output: Contribution to journalArticle

Stefani, A, Fedele, E, Galati, S, Pepicelli, O, Frasca, S, Pierantozzi, M, Peppe, A, Brusa, L, Orlacchio, A, Hainsworth, AH, Gattoni, G, Stanzione, P, Bernardi, G, Raiteri, M & Mazzone, P 2005, 'Subthalamic stimulation activates internal pallidus: Evidence from cGMP microdialysis in PD patients', Annals of Neurology, vol. 57, no. 3, pp. 448-452. https://doi.org/10.1002/ana.20402
Stefani A, Fedele E, Galati S, Pepicelli O, Frasca S, Pierantozzi M et al. Subthalamic stimulation activates internal pallidus: Evidence from cGMP microdialysis in PD patients. Annals of Neurology. 2005 Mar;57(3):448-452. https://doi.org/10.1002/ana.20402
Stefani, Alessandro ; Fedele, Ernesto ; Galati, Salvatore ; Pepicelli, Olimpia ; Frasca, Stefania ; Pierantozzi, Mariangela ; Peppe, Antonella ; Brusa, Livia ; Orlacchio, Antonio ; Hainsworth, Atticus H. ; Gattoni, Giuseppe ; Stanzione, Paolo ; Bernardi, Giorgio ; Raiteri, Maurizio ; Mazzone, Paolo. / Subthalamic stimulation activates internal pallidus : Evidence from cGMP microdialysis in PD patients. In: Annals of Neurology. 2005 ; Vol. 57, No. 3. pp. 448-452.
@article{0ead50ae201343b58ab64ce7badf5c0e,
title = "Subthalamic stimulation activates internal pallidus: Evidence from cGMP microdialysis in PD patients",
abstract = "Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN-DBS. This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi.",
author = "Alessandro Stefani and Ernesto Fedele and Salvatore Galati and Olimpia Pepicelli and Stefania Frasca and Mariangela Pierantozzi and Antonella Peppe and Livia Brusa and Antonio Orlacchio and Hainsworth, {Atticus H.} and Giuseppe Gattoni and Paolo Stanzione and Giorgio Bernardi and Maurizio Raiteri and Paolo Mazzone",
year = "2005",
month = "3",
doi = "10.1002/ana.20402",
language = "English",
volume = "57",
pages = "448--452",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Subthalamic stimulation activates internal pallidus

T2 - Evidence from cGMP microdialysis in PD patients

AU - Stefani, Alessandro

AU - Fedele, Ernesto

AU - Galati, Salvatore

AU - Pepicelli, Olimpia

AU - Frasca, Stefania

AU - Pierantozzi, Mariangela

AU - Peppe, Antonella

AU - Brusa, Livia

AU - Orlacchio, Antonio

AU - Hainsworth, Atticus H.

AU - Gattoni, Giuseppe

AU - Stanzione, Paolo

AU - Bernardi, Giorgio

AU - Raiteri, Maurizio

AU - Mazzone, Paolo

PY - 2005/3

Y1 - 2005/3

N2 - Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN-DBS. This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi.

AB - Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN-DBS. This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi.

UR - http://www.scopus.com/inward/record.url?scp=20044369699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20044369699&partnerID=8YFLogxK

U2 - 10.1002/ana.20402

DO - 10.1002/ana.20402

M3 - Article

VL - 57

SP - 448

EP - 452

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 3

ER -