Subthreshold depression and subjective cognitive complaints in Parkinson's disease

G. Santangelo, C. Vitale, L. Trojano, M. G. Angrisano, M. Picillo, D. Errico, V. Agosti, D. Grossi, P. Barone

Research output: Contribution to journalArticlepeer-review


Background and purpose: Subthreshold depression (SubD) is characterized by clinically relevant depressive symptoms not meeting criteria for major depression. The possible association of SubD with subjective cognitive complaints and/or objective cognitive impairments was investigated in a sample of consecutive, non-demented Parkinson's disease (PD) outpatients. Methods: Amongst 115 patients, SubD was identified in 30 patients, major depression in 33; 36 patients were classified as non-depressed. Enrolled patients were administered tests and questionnaires validated in PD for assessing objective and subjective cognitive dysfunctions. Results: On objective cognitive measures SubD patients did not differ from non-depressed patients, whereas depressed patients achieved significantly lower scores than the other two groups. SubD and depressed patients reported more cognitive complaints than non-depressed patients. Conclusions: SubD is a non-motor aspect of PD that is not related to objective cognitive deficits but is associated with subjective cognitive complaints, thus impacting on patients' well-being.

Original languageEnglish
Pages (from-to)541-544
Number of pages4
JournalEuropean Journal of Neurology
Issue number3
Publication statusPublished - Mar 2014


  • Cognitive dysfunctions
  • Depression
  • Parkinson's disease
  • Subjective cognitive complaints
  • Subthreshold depression

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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