Abstract
Objective: To compare the extent of subtle cerebral damage (SCD) in patients undergoing carotid endarterectomy with or without shunt placement. Design: Prospective, randomised study. Patients and methods: We assessed a consecutive series of 96 patients undergoing endarterectomy for severe unilateral left carotid stenosis who had been randomly assigned to receive a shunt (48) or not (48). Eligibility criteria included age up to 80 years and Mini-Mental State Examination score >24 points. Patients underwent neuropsychological testing before surgery. Serum concentrations of S100 protein, neuron-specific enolase (NSE) and interleukin-6 (IL-6) were measured intraoperatively before and after carotid clamping. Finally, each patient underwent neuropsychological testing 3 weeks after surgery. Results: Patients with and without shunt had similar serum concentrations of S100 protein, NSE and IL-6 as well as similar neuropsychological test scores, all p > 0.05. Conclusions: There was no difference in subtle cerebral damage between patients randomized to receive a shunt or not.
Original language | English |
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Pages (from-to) | 546-551 |
Number of pages | 6 |
Journal | European Journal of Vascular and Endovascular Surgery |
Volume | 34 |
Issue number | 5 |
DOIs | |
Publication status | Published - Nov 1 2007 |
Keywords
- Carotid endarterectomy
- Carotid stenosis
- Neuropsychological test
- Subtle cerebral damage
ASJC Scopus subject areas
- Surgery
- Cardiology and Cardiovascular Medicine