Subtle Cerebral Damage after Shunting vs Non Shunting during Carotid Endarterectomy

D. Palombo, G. Lucertini, S. Mambrini, M. Zettin

Research output: Contribution to journalArticlepeer-review


Objective: To compare the extent of subtle cerebral damage (SCD) in patients undergoing carotid endarterectomy with or without shunt placement. Design: Prospective, randomised study. Patients and methods: We assessed a consecutive series of 96 patients undergoing endarterectomy for severe unilateral left carotid stenosis who had been randomly assigned to receive a shunt (48) or not (48). Eligibility criteria included age up to 80 years and Mini-Mental State Examination score >24 points. Patients underwent neuropsychological testing before surgery. Serum concentrations of S100 protein, neuron-specific enolase (NSE) and interleukin-6 (IL-6) were measured intraoperatively before and after carotid clamping. Finally, each patient underwent neuropsychological testing 3 weeks after surgery. Results: Patients with and without shunt had similar serum concentrations of S100 protein, NSE and IL-6 as well as similar neuropsychological test scores, all p > 0.05. Conclusions: There was no difference in subtle cerebral damage between patients randomized to receive a shunt or not.

Original languageEnglish
Pages (from-to)546-551
Number of pages6
JournalEuropean Journal of Vascular and Endovascular Surgery
Issue number5
Publication statusPublished - Nov 1 2007


  • Carotid endarterectomy
  • Carotid stenosis
  • Neuropsychological test
  • Subtle cerebral damage

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine


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