Abstract
Objective: To compare the extent of subtle cerebral damage (SCD) in patients undergoing carotid endarterectomy with or without shunt placement. Design: Prospective, randomised study. Patients and methods: We assessed a consecutive series of 96 patients undergoing endarterectomy for severe unilateral left carotid stenosis who had been randomly assigned to receive a shunt (48) or not (48). Eligibility criteria included age up to 80 years and Mini-Mental State Examination score >24 points. Patients underwent neuropsychological testing before surgery. Serum concentrations of S100 protein, neuron-specific enolase (NSE) and interleukin-6 (IL-6) were measured intraoperatively before and after carotid clamping. Finally, each patient underwent neuropsychological testing 3 weeks after surgery. Results: Patients with and without shunt had similar serum concentrations of S100 protein, NSE and IL-6 as well as similar neuropsychological test scores, all p > 0.05. Conclusions: There was no difference in subtle cerebral damage between patients randomized to receive a shunt or not.
| Original language | English |
|---|---|
| Pages (from-to) | 546-551 |
| Number of pages | 6 |
| Journal | European Journal of Vascular and Endovascular Surgery |
| Volume | 34 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 1 2007 |
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Keywords
- Carotid endarterectomy
- Carotid stenosis
- Neuropsychological test
- Subtle cerebral damage
ASJC Scopus subject areas
- Surgery
- Cardiology and Cardiovascular Medicine
Cite this
Subtle Cerebral Damage after Shunting vs Non Shunting during Carotid Endarterectomy. / Palombo, D.; Lucertini, G.; Mambrini, S.; Zettin, M.
In: European Journal of Vascular and Endovascular Surgery, Vol. 34, No. 5, 01.11.2007, p. 546-551.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subtle Cerebral Damage after Shunting vs Non Shunting during Carotid Endarterectomy
AU - Palombo, D.
AU - Lucertini, G.
AU - Mambrini, S.
AU - Zettin, M.
PY - 2007/11/1
Y1 - 2007/11/1
N2 - Objective: To compare the extent of subtle cerebral damage (SCD) in patients undergoing carotid endarterectomy with or without shunt placement. Design: Prospective, randomised study. Patients and methods: We assessed a consecutive series of 96 patients undergoing endarterectomy for severe unilateral left carotid stenosis who had been randomly assigned to receive a shunt (48) or not (48). Eligibility criteria included age up to 80 years and Mini-Mental State Examination score >24 points. Patients underwent neuropsychological testing before surgery. Serum concentrations of S100 protein, neuron-specific enolase (NSE) and interleukin-6 (IL-6) were measured intraoperatively before and after carotid clamping. Finally, each patient underwent neuropsychological testing 3 weeks after surgery. Results: Patients with and without shunt had similar serum concentrations of S100 protein, NSE and IL-6 as well as similar neuropsychological test scores, all p > 0.05. Conclusions: There was no difference in subtle cerebral damage between patients randomized to receive a shunt or not.
AB - Objective: To compare the extent of subtle cerebral damage (SCD) in patients undergoing carotid endarterectomy with or without shunt placement. Design: Prospective, randomised study. Patients and methods: We assessed a consecutive series of 96 patients undergoing endarterectomy for severe unilateral left carotid stenosis who had been randomly assigned to receive a shunt (48) or not (48). Eligibility criteria included age up to 80 years and Mini-Mental State Examination score >24 points. Patients underwent neuropsychological testing before surgery. Serum concentrations of S100 protein, neuron-specific enolase (NSE) and interleukin-6 (IL-6) were measured intraoperatively before and after carotid clamping. Finally, each patient underwent neuropsychological testing 3 weeks after surgery. Results: Patients with and without shunt had similar serum concentrations of S100 protein, NSE and IL-6 as well as similar neuropsychological test scores, all p > 0.05. Conclusions: There was no difference in subtle cerebral damage between patients randomized to receive a shunt or not.
KW - Carotid endarterectomy
KW - Carotid stenosis
KW - Neuropsychological test
KW - Subtle cerebral damage
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UR - http://www.scopus.com/inward/citedby.url?scp=34848857040&partnerID=8YFLogxK
U2 - 10.1016/j.ejvs.2007.05.028
DO - 10.1016/j.ejvs.2007.05.028
M3 - Article
C2 - 17681825
AN - SCOPUS:34848857040
VL - 34
SP - 546
EP - 551
JO - European Journal of Vascular and Endovascular Surgery
JF - European Journal of Vascular and Endovascular Surgery
SN - 1078-5884
IS - 5
ER -