Abstract
Background: There is still a matter of controversy whether a subtotal gastrectomy has the same therapeutic potential as a total gastrectomy in distal gastric cancer. Whether all or a subgroup of patients can benefit from total gastrectomy can be answered only by a randomized trial. Method: We therefore assembled a prospective randomized multi-institutional trial which has so far randomized 400 patients for total or subtotal gastrectomy and second level lymphadenectomy. Material: Patients with gastric carcinoma of the lower half of the stomach are eligible unless one of the following conditions exists: Age over 75 years, previous malignant neoplasia except skin cancer, previous gastric resection, high surgical risk, tumor located at less than six centimeters from cardia, tumors not radically resectable. Results: The accrual of patients is still in progress. The available results concern the mortality rate that is higher after total gastrectomy but not statistically different from subtotal resection.
| Original language | English |
|---|---|
| Pages (from-to) | 84-91 |
| Number of pages | 8 |
| Journal | Oncology Research and Treatment |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1992 |
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Keywords
- Gastric cancer
- Nutritional sequelae
- Subtotal gastrectomy
- Total gastrectomy
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Subtotal gastrectomy or 'en principle' total gastrectomy in cancer of the lower half of the stomach. / Bozzetti, F.; Bonfanti, G.; Gennari, L.
In: Oncology Research and Treatment, Vol. 15, No. 2, 1992, p. 84-91.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subtotal gastrectomy or 'en principle' total gastrectomy in cancer of the lower half of the stomach
AU - Bozzetti, F.
AU - Bonfanti, G.
AU - Gennari, L.
PY - 1992
Y1 - 1992
N2 - Background: There is still a matter of controversy whether a subtotal gastrectomy has the same therapeutic potential as a total gastrectomy in distal gastric cancer. Whether all or a subgroup of patients can benefit from total gastrectomy can be answered only by a randomized trial. Method: We therefore assembled a prospective randomized multi-institutional trial which has so far randomized 400 patients for total or subtotal gastrectomy and second level lymphadenectomy. Material: Patients with gastric carcinoma of the lower half of the stomach are eligible unless one of the following conditions exists: Age over 75 years, previous malignant neoplasia except skin cancer, previous gastric resection, high surgical risk, tumor located at less than six centimeters from cardia, tumors not radically resectable. Results: The accrual of patients is still in progress. The available results concern the mortality rate that is higher after total gastrectomy but not statistically different from subtotal resection.
AB - Background: There is still a matter of controversy whether a subtotal gastrectomy has the same therapeutic potential as a total gastrectomy in distal gastric cancer. Whether all or a subgroup of patients can benefit from total gastrectomy can be answered only by a randomized trial. Method: We therefore assembled a prospective randomized multi-institutional trial which has so far randomized 400 patients for total or subtotal gastrectomy and second level lymphadenectomy. Material: Patients with gastric carcinoma of the lower half of the stomach are eligible unless one of the following conditions exists: Age over 75 years, previous malignant neoplasia except skin cancer, previous gastric resection, high surgical risk, tumor located at less than six centimeters from cardia, tumors not radically resectable. Results: The accrual of patients is still in progress. The available results concern the mortality rate that is higher after total gastrectomy but not statistically different from subtotal resection.
KW - Gastric cancer
KW - Nutritional sequelae
KW - Subtotal gastrectomy
KW - Total gastrectomy
UR - http://www.scopus.com/inward/record.url?scp=0026566250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026566250&partnerID=8YFLogxK
U2 - 10.1159/000217341
DO - 10.1159/000217341
M3 - Article
VL - 15
SP - 84
EP - 91
JO - Oncology Research and Treatment
JF - Oncology Research and Treatment
SN - 2296-5270
IS - 2
ER -