Subtotal gastrectomy or 'en principle' total gastrectomy in cancer of the lower half of the stomach

F. Bozzetti, G. Bonfanti, L. Gennari

Research output: Contribution to journalArticlepeer-review


Background: There is still a matter of controversy whether a subtotal gastrectomy has the same therapeutic potential as a total gastrectomy in distal gastric cancer. Whether all or a subgroup of patients can benefit from total gastrectomy can be answered only by a randomized trial. Method: We therefore assembled a prospective randomized multi-institutional trial which has so far randomized 400 patients for total or subtotal gastrectomy and second level lymphadenectomy. Material: Patients with gastric carcinoma of the lower half of the stomach are eligible unless one of the following conditions exists: Age over 75 years, previous malignant neoplasia except skin cancer, previous gastric resection, high surgical risk, tumor located at less than six centimeters from cardia, tumors not radically resectable. Results: The accrual of patients is still in progress. The available results concern the mortality rate that is higher after total gastrectomy but not statistically different from subtotal resection.

Original languageEnglish
Pages (from-to)84-91
Number of pages8
JournalOncology Research and Treatment
Issue number2
Publication statusPublished - 1992


  • Gastric cancer
  • Nutritional sequelae
  • Subtotal gastrectomy
  • Total gastrectomy

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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