Subtypes of β-adrenergic receptors in rat cerebral microvessels

Hideyuki Kobayashi, Tiziana Maoret, Marco Ferrante, Pierfranco Spano, Marco Trabucchi

Research output: Contribution to journalArticle

Abstract

The 125I-labeled iodohydroxybenzylpindolol (IHYP) binding to β-receptors on brain microvessels is inhibited by isoproterenol, epinephrine and norepinephrine, with Ki values of 2 × 10-7 M, 2.5 × 10-6 M and 1.2 × 10-5 M, respectively. A modified Scatchard analysis of the inhibitory effects of practolol, metroprolol and zinterol on IHYP binding has shown that the proportion of β2-receptors in our preparation is about 80% of the total β-adrenergic receptor population. Our data indicate that the β-adrenergic receptors located on cerebral microvessels are of both β1 and β2 types, with a predominance of the β2 type.

Original languageEnglish
Pages (from-to)194-198
Number of pages5
JournalBrain Research
Volume220
Issue number1
DOIs
Publication statusPublished - Sep 7 1981

Keywords

  • cerebral microvessels
  • iodohydroxybenzylpindolol
  • β-receptor subtypes

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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  • Cite this

    Kobayashi, H., Maoret, T., Ferrante, M., Spano, P., & Trabucchi, M. (1981). Subtypes of β-adrenergic receptors in rat cerebral microvessels. Brain Research, 220(1), 194-198. https://doi.org/10.1016/0006-8993(81)90225-0