Subtypes of Epstein-Barr virus in HIV-1-associated and HIV-1-unrelated Hodgkin's disease cases

V. De Re, M. Boiocchi, S. De Vita, R. Dolcetti, A. Gloghini, S. Uccini, C. Baroni, A. Scarpa, G. Cattoretti, A. Carbone

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Abstract

Epstein-Barr virus (EBV) type 2 is considered to be a much less potent transformer of lymphocytes than type 1. However, type-2 EBV may be involved in the pathogenesis of non-Hodgkin's lymphomas (NHLs) arising in immunocompromised patients, i.e., subjects with malaria or HIV-1 infection. To determine whether type-2 EBV may also play a role in Hodgkin's disease (HD) developing in immunocompromised patients, we characterized EBV subtypes in EBV-positive HD samples from 10 HIV-1-positive patients as well as from a control population of 24 HIV-1-negative patients. Type-2 EBV was detected in 5/10 HD samples from the HIV-1-positive group (1 case showed concomitant type-1 EBV positivity), but only in 1/20 HD samples from the HIV-1-negative group, indicating that, during HIV-1-induced immunodepression, type-2 EBV may be pathogenetically involved also in HD, as previously reported for HIV-associated NHLs.

Original languageEnglish
Pages (from-to)895-898
Number of pages4
JournalInternational Journal of Cancer
Volume54
Issue number6
Publication statusPublished - 1993

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Human Herpesvirus 4
Hodgkin Disease
HIV-1
Immunocompromised Host
Non-Hodgkin's Lymphoma
Immunosuppression
Malaria
HIV Infections
HIV
Lymphocytes
Population

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Subtypes of Epstein-Barr virus in HIV-1-associated and HIV-1-unrelated Hodgkin's disease cases. / De Re, V.; Boiocchi, M.; De Vita, S.; Dolcetti, R.; Gloghini, A.; Uccini, S.; Baroni, C.; Scarpa, A.; Cattoretti, G.; Carbone, A.

In: International Journal of Cancer, Vol. 54, No. 6, 1993, p. 895-898.

Research output: Contribution to journalArticle

De Re, V, Boiocchi, M, De Vita, S, Dolcetti, R, Gloghini, A, Uccini, S, Baroni, C, Scarpa, A, Cattoretti, G & Carbone, A 1993, 'Subtypes of Epstein-Barr virus in HIV-1-associated and HIV-1-unrelated Hodgkin's disease cases', International Journal of Cancer, vol. 54, no. 6, pp. 895-898.
De Re, V. ; Boiocchi, M. ; De Vita, S. ; Dolcetti, R. ; Gloghini, A. ; Uccini, S. ; Baroni, C. ; Scarpa, A. ; Cattoretti, G. ; Carbone, A. / Subtypes of Epstein-Barr virus in HIV-1-associated and HIV-1-unrelated Hodgkin's disease cases. In: International Journal of Cancer. 1993 ; Vol. 54, No. 6. pp. 895-898.
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