Indice di rischio per cancro gastrico nei pazienti con lesioni precancerose dello stomaco ed infezione da helicobacter pylori

The follow-up of preneoplastic gastric lesions (PGL) is a controversal problem, because only few patients with chronic atrophic gastritis (CAG) and intestinal metaplasia (IM) develop cancer. Recently a simple score has been proposed to detect Helicobacter pylory (Hp) infected patients with an increased risk for gastric cancer (GC). The aim of our study was to compare three groups of patients: 36 with CAG ant type I IM, 25 with type III IM and 41 with duodenal ulcer (DU), characterized by Hp infection, to assess the difference of lymphocytes/plasmacells and neutrophiles infiltration in corpus and antrum and to calculate gastric carcinoma risk index according to the different features to discriminate the groups of patients with different cancer risk, without considering IM. Patients with PGL had not a higher lymphocytes/plasmacells and neutrophiles infiltration in the corpus when compared to the antral infiltration. Subjects with CAG and type III IM had higher infiltration for lymphocytes/plasmacells and neutrophiles, in the gastric corpus, than DU patients (40% vs 14.63%, 44% vs 14.63%; p