Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports

Lucia Taramasso, Chiara Dentone, Anna Alessandrini, Bianca Bruzzone, Giancarlo Icardi, Rodolphe Garraffo, Ilaria De Macina, Claudio Viscoli, Antonio Di Biagio

Research output: Contribution to journalArticlepeer-review

Abstract

In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i.e. enfuvirtide in the first case and etravirine in the second one.

Original languageEnglish
Pages (from-to)831-834
Number of pages4
JournalInternational Journal of STD and AIDS
Volume26
Issue number11
DOIs
Publication statusPublished - Oct 24 2015

Keywords

  • AIDS
  • antiretroviral therapy
  • darunavir
  • dolutegravir
  • HIV
  • resistance
  • treatment
  • treatment experienced

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases
  • Medicine(all)

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