Background: Clear cell acanthoma (CCA) is a usually solitary benign epidermal tumor. Multiple lesions are infrequently reported. Objective: A case of multiple eruptive CCA is reported in which a successful cryotherapic treatment was performed. Methods: A 59-year-old man with varicose veins and dry skin presented with 17 eruptive asymptomatic papulo-nodular lesions on both legs. Results: Two lesions were excised with a histologically confirmed diagnosis of CCA. Other lesions were treated with liquid nitrogen. All the lesions resolved with minimal residual scarring after three to four treatments. Conclusions: Multiple CCA is a rare condition; fewer than 20 cases having been described. The presence of associated conditions like dry skin and varicose veins are discussed. Because of the tendency of persistence of the lesions, cryotherapic treatment may be a useful method of therapy.
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