Successful reduction of in-stent restenosis in long lesions using β-radiation - Subanalysis from the RENO registry

Dietrich Baumgart, Raoul Bonan, Christoph Naber, Patrick Serruys, Antonio Colombo, Sigmund Silber, Eric Eeckhout, Philip Urban

Research output: Contribution to journalArticlepeer-review


Purpose: Long lesions remain a challenging task in interventional cardiology, with a high propensity of restenosis, especially within the stented segment. Although intracoronary γ-radiation has been proved to reduce diffuse in-stent restenosis in long lesions, such an effect remains to be determined using β-radiation. Methods and Materials: Of 1098 consecutive patients at 46 European centers treated with localized β-radiation ( 90Sr, Novoste Beta-Cath System), 139 patients (mean age 61.5 ± 10.7 years, 84% male, 22% with diabetes mellitus) with lesions treated using a >40-mm source length underwent radiation using a single 60-mm source train (34%) or a stepping/pullback procedure with a 30-mm (12%) or 40-mm (87%) source length after conventional interventional procedures. The mean lesion length was 35.3 ± 17.9 mm. Results: Technical success was achieved in 96% of cases. Geographic miss was noted in 9 patients (6.5%). The reference (placebo) group was obtained from the Washington Hospital Center for In-Stent Restenosis Trial (WRIST) and the WRIST Trial for long lesions (LONG WRIST) studies by selecting the cases (94 patients) that required a dummy source length ≥13 seeds (or >51 mm in length). Statistically significant improvement was noted in late angiographic restenosis (34.7% vs. 76.5%, p

Original languageEnglish
Pages (from-to)817-827
Number of pages11
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number3
Publication statusPublished - Mar 2004


  • β-Radiation
  • In-stent restenosis
  • Long lesions

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation


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