Abstract
Purpose: Long lesions remain a challenging task in interventional cardiology, with a high propensity of restenosis, especially within the stented segment. Although intracoronary γ-radiation has been proved to reduce diffuse in-stent restenosis in long lesions, such an effect remains to be determined using β-radiation. Methods and Materials: Of 1098 consecutive patients at 46 European centers treated with localized β-radiation ( 90Sr, Novoste Beta-Cath System), 139 patients (mean age 61.5 ± 10.7 years, 84% male, 22% with diabetes mellitus) with lesions treated using a >40-mm source length underwent radiation using a single 60-mm source train (34%) or a stepping/pullback procedure with a 30-mm (12%) or 40-mm (87%) source length after conventional interventional procedures. The mean lesion length was 35.3 ± 17.9 mm. Results: Technical success was achieved in 96% of cases. Geographic miss was noted in 9 patients (6.5%). The reference (placebo) group was obtained from the Washington Hospital Center for In-Stent Restenosis Trial (WRIST) and the WRIST Trial for long lesions (LONG WRIST) studies by selecting the cases (94 patients) that required a dummy source length ≥13 seeds (or >51 mm in length). Statistically significant improvement was noted in late angiographic restenosis (34.7% vs. 76.5%, p
| Original language | English |
|---|---|
| Pages (from-to) | 817-827 |
| Number of pages | 11 |
| Journal | International Journal of Radiation Oncology Biology Physics |
| Volume | 58 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2004 |
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Keywords
- β-Radiation
- In-stent restenosis
- Long lesions
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Radiation
Cite this
Successful reduction of in-stent restenosis in long lesions using β-radiation - Subanalysis from the RENO registry. / Baumgart, Dietrich; Bonan, Raoul; Naber, Christoph; Serruys, Patrick; Colombo, Antonio; Silber, Sigmund; Eeckhout, Eric; Urban, Philip.
In: International Journal of Radiation Oncology Biology Physics, Vol. 58, No. 3, 03.2004, p. 817-827.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Successful reduction of in-stent restenosis in long lesions using β-radiation - Subanalysis from the RENO registry
AU - Baumgart, Dietrich
AU - Bonan, Raoul
AU - Naber, Christoph
AU - Serruys, Patrick
AU - Colombo, Antonio
AU - Silber, Sigmund
AU - Eeckhout, Eric
AU - Urban, Philip
PY - 2004/3
Y1 - 2004/3
N2 - Purpose: Long lesions remain a challenging task in interventional cardiology, with a high propensity of restenosis, especially within the stented segment. Although intracoronary γ-radiation has been proved to reduce diffuse in-stent restenosis in long lesions, such an effect remains to be determined using β-radiation. Methods and Materials: Of 1098 consecutive patients at 46 European centers treated with localized β-radiation ( 90Sr, Novoste Beta-Cath System), 139 patients (mean age 61.5 ± 10.7 years, 84% male, 22% with diabetes mellitus) with lesions treated using a >40-mm source length underwent radiation using a single 60-mm source train (34%) or a stepping/pullback procedure with a 30-mm (12%) or 40-mm (87%) source length after conventional interventional procedures. The mean lesion length was 35.3 ± 17.9 mm. Results: Technical success was achieved in 96% of cases. Geographic miss was noted in 9 patients (6.5%). The reference (placebo) group was obtained from the Washington Hospital Center for In-Stent Restenosis Trial (WRIST) and the WRIST Trial for long lesions (LONG WRIST) studies by selecting the cases (94 patients) that required a dummy source length ≥13 seeds (or >51 mm in length). Statistically significant improvement was noted in late angiographic restenosis (34.7% vs. 76.5%, p
AB - Purpose: Long lesions remain a challenging task in interventional cardiology, with a high propensity of restenosis, especially within the stented segment. Although intracoronary γ-radiation has been proved to reduce diffuse in-stent restenosis in long lesions, such an effect remains to be determined using β-radiation. Methods and Materials: Of 1098 consecutive patients at 46 European centers treated with localized β-radiation ( 90Sr, Novoste Beta-Cath System), 139 patients (mean age 61.5 ± 10.7 years, 84% male, 22% with diabetes mellitus) with lesions treated using a >40-mm source length underwent radiation using a single 60-mm source train (34%) or a stepping/pullback procedure with a 30-mm (12%) or 40-mm (87%) source length after conventional interventional procedures. The mean lesion length was 35.3 ± 17.9 mm. Results: Technical success was achieved in 96% of cases. Geographic miss was noted in 9 patients (6.5%). The reference (placebo) group was obtained from the Washington Hospital Center for In-Stent Restenosis Trial (WRIST) and the WRIST Trial for long lesions (LONG WRIST) studies by selecting the cases (94 patients) that required a dummy source length ≥13 seeds (or >51 mm in length). Statistically significant improvement was noted in late angiographic restenosis (34.7% vs. 76.5%, p
KW - β-Radiation
KW - In-stent restenosis
KW - Long lesions
UR - http://www.scopus.com/inward/record.url?scp=1242315589&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1242315589&partnerID=8YFLogxK
U2 - 10.1016/S0360-3016(03)01615-8
DO - 10.1016/S0360-3016(03)01615-8
M3 - Article
C2 - 14967439
AN - SCOPUS:1242315589
VL - 58
SP - 817
EP - 827
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
SN - 0360-3016
IS - 3
ER -