TY - JOUR
T1 - Successful Treatment of Macular Retinoblastoma With Superselective Ophthalmic Artery Infusion of Melphalan
AU - Hadjistilianou, Theodora
AU - Coriolani, Gianni
AU - Bracco, Sandra
AU - Gennari, Paola
AU - Caini, Mauro
AU - Cerase, Alfonso
AU - Galimberti, Daniela
AU - Francesco, Sonia De
AU - Luca, Mariacarla De
AU - Mastrangelo, Domenico
PY - 2014/1
Y1 - 2014/1
N2 - Purpose: To report our experience with superselective ophthalmic artery infusion of melphalan (SOAIM) for macular retinoblastoma to obtain tumor control while preserving as much useful vision as possible. Methods: Five patients with newly diagnosed unilateral retinoblastoma involving the macula were selected within a group of patients eligible for SOAIM as the primary treatment. Results: The mean tumor basal dimension and thickness in this group of five patients with macular retinoblastoma were 11.6 and 12.3 mm, respectively. The stage at diagnosis ranged from II to VB (Reese-Ellsworth) or B to D (International Classification System). Tumor regression with SOAIM was achieved in all cases with regression patterns type I in four cases and III in one case. Conclusions: SOAIM can be of value in the treatment of macular retinoblastoma. It may allow the salvage of the residual eyesight with a low rate of complications due to the local and systemic toxicity related to chemotherapy.
AB - Purpose: To report our experience with superselective ophthalmic artery infusion of melphalan (SOAIM) for macular retinoblastoma to obtain tumor control while preserving as much useful vision as possible. Methods: Five patients with newly diagnosed unilateral retinoblastoma involving the macula were selected within a group of patients eligible for SOAIM as the primary treatment. Results: The mean tumor basal dimension and thickness in this group of five patients with macular retinoblastoma were 11.6 and 12.3 mm, respectively. The stage at diagnosis ranged from II to VB (Reese-Ellsworth) or B to D (International Classification System). Tumor regression with SOAIM was achieved in all cases with regression patterns type I in four cases and III in one case. Conclusions: SOAIM can be of value in the treatment of macular retinoblastoma. It may allow the salvage of the residual eyesight with a low rate of complications due to the local and systemic toxicity related to chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=84894057773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894057773&partnerID=8YFLogxK
U2 - 10.3928/01913913-20131203-01
DO - 10.3928/01913913-20131203-01
M3 - Article
C2 - 24308859
AN - SCOPUS:84894057773
VL - 51
SP - 32
EP - 38
JO - Journal of Pediatric Ophthalmology and Strabismus
JF - Journal of Pediatric Ophthalmology and Strabismus
SN - 0191-3913
IS - 1
ER -