Scabbia norvegese ed epidermolisi bollosa distrofica recessiva: Efficacia della terapia con ivermectina

Translated title of the contribution: Successful treatment of Norwegian scabies with ivermectin in a patient with recessive dystrophic epidermolysis bullosa

C. Angelo, C. Pedicelli, A. Provini, G. Annessi, G. Zambruno, M. Paradisi

Research output: Contribution to journalArticle

Abstract

A 14 year-old female born from consanguineous healthy parents was admitted to our institute for the presence of a generalized bullous eruption started at birth. The bullae were asymmetrically distributed all over the cutaneous surface and, over time, evolved into erosions that resolved with scarring areas. On the basis of the clinical picture and the ultrastructural and antigenic studies, a diagnosis of recessive dystrophic epidermolysis bullosa was made. In the following months, the patient began to complain a severe pruritus and the bullae and erosions were accompanied with diffuse erythematous patches and plaques covered by thick scale-crusts situated mostly on the arms. Microscopic examination of the scales revealed the presence of many mites and ova. Since the conventional topical therapies for scabies were uneffective, the patient was treated with a single dose (200 mcg/hg) of ivermectin. Although there was an initial improvement, scabies recurred within 2 months from discontinuation of the therapy. Finally, a further single administration of ivermectin at the same dosage led to the complete and permanent resolution of scabies. The association of recessive dystrophic epidermolysis bullosa and norvwegian scabies has been already reported in literature. The case presented suggests that ivermectin represents an effective drug for severe forms of scabies occurring in patients affected by other dermatoses that prevent the use of topical treatments.

Original languageItalian
Pages (from-to)353-357
Number of pages5
JournalMinerva Pediatrica
Volume56
Issue number3
Publication statusPublished - Jun 2004

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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