Successful treatment of secondary acute myeloid leukemia relapsing after allogeneic bone marrow transplantation with donor lymphocyte infusion failed to prevent recurrence of primary disease: A case report

S. Cesaro, C. Messina, A. Rosolen, M. C. Putti, L. Sainati, R. Destro, M. V. Gazzola, S. Varotto, G. De Silvestro, G. Scarzello, M. Spinelli, M. Pillon, L. Zanesco

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of therapy-related secondary acute myeloid leukemia occurring in a patient during treatment for anaplastic large cell lymphoma. In spite of response to induction chemotherapy and prompt bone marrow transplantation from his matched sister, the patient experienced an early leukemia relapse within 3 months of the transplant. Treatment with oral etoposide for 3 weeks followed by donor lymphocyte infusion achieved a 7-month remission from leukemia without any further treatment. Unfortunately, the patient suffered a recurrence of the primary anaplastic large cell lymphoma that was treated by resuming chemotherapy and local radiotherapy. The patient died 20 months after DLI, still in CR for his leukemia, due to ALCL progression.

Original languageEnglish
Pages (from-to)625-628
Number of pages4
JournalBone Marrow Transplantation
Volume23
Issue number6
Publication statusPublished - 1999

Keywords

  • Allogeneic bone marrow transplantation
  • Anaplastic large cell lymphoma
  • Donor lymphocyte infusion
  • Immunotherapy

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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