Successful treatment of trilateral retinoblastoma with conventional and high-dose chemotherapy plus radiotherapy: A case report

Maria Antonietta De Ioris, Paola Fidani, Francis L. Munier, Annalisa Serra, Ilaria Ilari, Maya Beck Popovic, Gianluigi Natali, Domitilla Elena Secco, Raffaele Cozza

Research output: Contribution to journalArticle

Abstract

Trilateral retinoblastoma (TRB) is a rare condition characterized by an intracranial neuroblastic tumor associated with bilateral or unilateral retinoblastoma (RB). The outcome is almost always fatal. An 18-month-old patient with familial bilateral RB was referred for a pineal lesion detected on a screening by magnetic resonance imaging. The child, considered inoperable by 2 different neurosurgical teams, was treated with conventional chemotherapy (methotrexate, vincristine, vepeside, cyclophosphamide, and carboplatin) plus tandem transplantation (vepeside/carboplatin and thiotepa/mephalan) followed by local radiotherapy. At 80 months from the diagnosis of TRB, the patient is alive and in complete remission, with no neuropsychologic consequences. An early and aggressive treatment may improve the prognosis of TRB.

Original languageEnglish
JournalJournal of Pediatric Hematology/Oncology
Volume32
Issue number8
DOIs
Publication statusPublished - Nov 2010

Keywords

  • high-dose chemotherapy
  • survival
  • trilateral retinoblastoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology
  • Medicine(all)

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