Successful treatment with GEMOX in patient with metastatic pancreatic adenosquamous carcinoma

Gaetano Aurilio, Teresa Macarulla, Javier Francisco Ramos, Nicola Fazio, Franco Nolè, Carmela Iglesias

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background. Pancreatic adenosquamous carcinoma (PASC) is a rare subtype of pancreatic cancer characterized by a dual histological component and aggressive behavior. This form is not well known, its histogenesis is uncertain, and there are different opinions on the diagnostic histopathological criteria. The differential diagnosis with more common ductal adenocarcinoma, squamous cell carcinoma, squamous or adenosquamous metastases is complex. The available therapies do not improve the poor prognosis and it is difficult to find long-term survivors (more than 1 year), even after demolitive surgery with complementary therapies. Case report.We report a case of advanced PASC with excellent progression-free survival and overall survival, 20months and 29months, respectively. Furthermore, an almost complete response was obtained to first-line chemotherapy with gemcitabine/oxaliplatin (GEMOX) followed by maintenance gemcitabine. Conclusion. GEMOX followed by gemcitabine as maintenance could be an effective treatment for this pancreatic entity. Further reports are needed to confirm this outcome.

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalTumori
Volume97
Issue number2
Publication statusPublished - Mar 2011

Fingerprint

oxaliplatin
gemcitabine
Adenosquamous Carcinoma
Maintenance
Therapeutics
Complementary Therapies
Pancreatic Neoplasms
Disease-Free Survival
Survivors
Squamous Cell Carcinoma
Adenocarcinoma
Differential Diagnosis
Neoplasm Metastasis
Drug Therapy
Survival
Pancreatic Carcinoma

Keywords

  • Adenosquamous carcinoma
  • GEMOX
  • Metastatic pancreatic cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Successful treatment with GEMOX in patient with metastatic pancreatic adenosquamous carcinoma. / Aurilio, Gaetano; Macarulla, Teresa; Ramos, Javier Francisco; Fazio, Nicola; Nolè, Franco; Iglesias, Carmela.

In: Tumori, Vol. 97, No. 2, 03.2011, p. 239-242.

Research output: Contribution to journalArticle

Aurilio, Gaetano ; Macarulla, Teresa ; Ramos, Javier Francisco ; Fazio, Nicola ; Nolè, Franco ; Iglesias, Carmela. / Successful treatment with GEMOX in patient with metastatic pancreatic adenosquamous carcinoma. In: Tumori. 2011 ; Vol. 97, No. 2. pp. 239-242.
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