Successful treatment with Protein C of febrile neutropenia in pediatric patients during cancer therapy

Paola Giordano, Valerio Cecinati, Giovanni Carlo Vecchio, Giampaolo Arcamone, Francesco De Leonardis, Massimo Grassi, Letizia Pomponia Brescia, Nicola Santoro, Domenico De Mattia

Research output: Contribution to journalArticlepeer-review

Abstract

Febrile Neutropenia (FN) is a complication of chemotherapy in childhood cancer and at the same time secondary deficit of Protein C (PC) is often present during sepsis in children with cancer. In this study we have compared the clinical outcome of two different groups. At the onset of FN during chemotherapy the first group (patients with a secondary deficit of PC) received Protein C Concentrate (PCC) replacement while the other group without PC deficiency received only symptomatic therapies. We report that PC replacement could shorten duration of FN and improve the clinical outcome. The administration of PCC was safe and without any complications.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalImmunopharmacology and Immunotoxicology
Volume31
Issue number2
DOIs
Publication statusPublished - 2009

Keywords

  • Cancer
  • Children
  • Febrile neutropenia
  • Protein C

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Successful treatment with Protein C of febrile neutropenia in pediatric patients during cancer therapy'. Together they form a unique fingerprint.

Cite this