Successful use of tissue plasminogen activator (t-PA) in catheter- related intracardiac thrombi of two premature infants

B. Giuffrè, G. Compagnoni, C. Farina, F. Mosca

Research output: Contribution to journalArticle

Abstract

We describe the cases of two premature infants carrying a central venous line who developed on the fourth day of life a catheter related intracardiac thrombus. Although they were clinically asymptomatic we opted for thrombolytic treatment considering the potential risks of this situation. Treatment with recombinant tissue plasminogen activator (rt-PA) was performed for one day in the first case and for three days in the second one, in association with fresh frozen plasma. Thrombus dissolution occurred in both patients and no adverse effects were noted. In our experience tissue plasminogen activator was a therapy acceptably safe and effective inducing clot lysis in very low birthweight neonates into critical situations.

Original languageEnglish
Pages (from-to)695-698
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume87
Issue number6
DOIs
Publication statusPublished - 1998

Keywords

  • Catheter
  • Intracardiac thrombus
  • Preterm infants
  • Tissue plasminogen activator

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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