Sucralfate in the treatment of chemotherapy-induced stomatitis: A double-blind, placebo-controlled pilot study

Silvana Chiara, Maria Teresa Nobile, Maura Vincenti, Alberto Gozza, Ilaria Pastrone, Matteo Rosso, Riccardo Rosso

Research output: Contribution to journalArticle

Abstract

Background: The study was a double-blind, placebo-controlled, randomised pilot study to assess the efficacy of sucralfate gel in the treatment of chemotherapy-induced mucositis. Patients and Methods: At the onset of stomatitis, forty patients received sucralfate gel (1 gr.) or placebo and were instructed to apply the gel over oral mucosas, 3 times daily. Results: Objective response was observed in 14 patients (11 complete response+3 partial response) and in 15 patients (10 CR + 5 PR), in the sucralfate and placebo arms, respectively; (p = NS). Analysis of VAS (visual analogue scale) scoring of pain did not detect any statistical difference between the two groups. No important side-effects were observed. Twelve out 21 patients who obtained a complete resolution of stomatitis (5 out of 11 and 7 out of 10 in the sucralfate and in placebo arms, respectively) received further treatment at the subsequent course of chemotherapy: prevention of mucositis was observed in 4 patients in the sucralfate arm and in 6 patients in the placebo arm, respectively. Conclusion: In the present pilot study, sucralfate did not demonstrate a significant advantage in comparison to the placebo in the treatment of chemotherapy-induced stomatitis.

Original languageEnglish
Pages (from-to)3707-3710
Number of pages4
JournalAnticancer Research
Volume21
Issue number5
Publication statusPublished - 2001

Keywords

  • Chemotherapy
  • Mucositis
  • Side-effects
  • Sucralfate

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Chiara, S., Nobile, M. T., Vincenti, M., Gozza, A., Pastrone, I., Rosso, M., & Rosso, R. (2001). Sucralfate in the treatment of chemotherapy-induced stomatitis: A double-blind, placebo-controlled pilot study. Anticancer Research, 21(5), 3707-3710.