TY - JOUR
T1 - Sudden coronary death, fatal acute myocardial infarction and widespread coronary and myocardial inflammation
AU - Abbate, A.
AU - Bussani, R.
AU - Liuzzo, G.
AU - Biondi-Zoccai, G. G L
AU - Barresi, E.
AU - Mellone, P.
AU - Sinagra, G.
AU - Dobrina, A.
AU - De Giorgio, F.
AU - Sharma, R.
AU - Bassan, F.
AU - Severino, A.
AU - Baldi, F.
AU - Biasucci, L. M.
AU - Pandolfi, F.
AU - Silvestri, F.
AU - Vetrovec, G. W.
AU - Baldi, A.
AU - Crea, F.
PY - 2008/6
Y1 - 2008/6
N2 - Background: T-lymphocyte activation within atherosclerotic plaque, and widespread to the myocardium, has been shown in patients with acute coronary syndromes. Objective: To investigate the presence of T-lymphocyte infiltrate at different stages of acute coronary syndromes by studying patients with sudden coronary death, acute myocardial infarction (AMI) and healed infarction, in comparison with patients with myocarditis and patients with non-ischaemic heart failure. Methods: 72 cases were studied at autopsy: 12 dying of sudden coronary death (group 1), 12 dying 4 months after AMI (group 3), 12 with active lymphocytic myocarditis (group 4), 12 with hypertensive heart disease (group 5), and 12 control subjects (group 6). Light microscopy was performed to measure the number of activated T-lymphocytes (CD3+/DR+) in the myocardium and coronary artery wall, and intercellular adhesion molecule-1 (ICAM-1) expression in the myocardium. Results: Activated T-lymphocyte infiltrates and ICAM-1 myocardial expression in both remote and peri-infarction regions and activated T-lymphocytes within the epicardial coronary artery wall of both the infarct- and non-infarct-related arteries were found in groups 1, 2 and 3, whereas myocardial, but not coronary, infiltrates were found in groups 4 (p
AB - Background: T-lymphocyte activation within atherosclerotic plaque, and widespread to the myocardium, has been shown in patients with acute coronary syndromes. Objective: To investigate the presence of T-lymphocyte infiltrate at different stages of acute coronary syndromes by studying patients with sudden coronary death, acute myocardial infarction (AMI) and healed infarction, in comparison with patients with myocarditis and patients with non-ischaemic heart failure. Methods: 72 cases were studied at autopsy: 12 dying of sudden coronary death (group 1), 12 dying 4 months after AMI (group 3), 12 with active lymphocytic myocarditis (group 4), 12 with hypertensive heart disease (group 5), and 12 control subjects (group 6). Light microscopy was performed to measure the number of activated T-lymphocytes (CD3+/DR+) in the myocardium and coronary artery wall, and intercellular adhesion molecule-1 (ICAM-1) expression in the myocardium. Results: Activated T-lymphocyte infiltrates and ICAM-1 myocardial expression in both remote and peri-infarction regions and activated T-lymphocytes within the epicardial coronary artery wall of both the infarct- and non-infarct-related arteries were found in groups 1, 2 and 3, whereas myocardial, but not coronary, infiltrates were found in groups 4 (p
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U2 - 10.1136/hrt.2007.115329
DO - 10.1136/hrt.2007.115329
M3 - Article
C2 - 17698556
AN - SCOPUS:44349135688
VL - 94
SP - 737
EP - 742
JO - Heart
JF - Heart
SN - 1355-6037
IS - 6
ER -