Sudden Death in End Stage Renal Disease: Comparing Hemodialysis versus Peritoneal Dialysis

Simonetta Genovesi, Luca Porcu, Maria Carmen Luise, Hilary Riva, Elisa Nava, Gina Contaldo, Andrea Stella, Claudio Pozzi, Patrizia Ondei, Claudio Minoretti, Maurizio Gallieni, Giuseppe Pontoriero, Ferruccio Conte, Valter Torri, Silvio Bertoli, Antonio Vincenti

Research output: Contribution to journalArticlepeer-review


Background/Aims: This study aimed to evaluate total and sudden death (SD) in a cohort of dialysis patients, comparing hemodialysis (HD) vs. peritoneal dialysis (PD). Methods: This is a multicenter retrospective cohort study. Results: Deaths were 626 out of 1,823 in HD and 62 of 249 in PD patients. HD patients had a greater number of comorbidities (p < 0.05). PD patients had a lower risk of death than HD patients (p < 0.001); however, the advantage decreased with time (p < 0.001). Mortality predictors were left ventricular ejection fraction (LVEF) ≤35%, older age, ischemic heart disease, diabetes mellitus, previous stroke, and atrial fibrillation (p < 0.03). SDs were 84:71 in HD and 13 in PD population (12.1 and 22.8% of all causes of death, respectively). A non-significant risk of SD among PD compared to HD patients was detected. SD predictors were older age, ischemic heart disease, and LVEF ≤35% (p < 0.05). Conclusions: HD patients showed a greater presence of comorbidities and reduced survival compared to PD patients; however, the incidence of SD does not differ in the 2 populations. Video Journal Club "Cappuccino with Claudio Ronco" at

Original languageEnglish
Pages (from-to)77-88
Number of pages12
JournalBlood Purification
Issue number1
Publication statusPublished - Apr 1 2017


  • Hemodialysis
  • Mortality
  • Peritoneal dialysis
  • Regression models
  • Sudden death

ASJC Scopus subject areas

  • Hematology
  • Nephrology


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