Sudden death in Prader-Willi syndrome during growth hormone therapy

Michele Sacco, Girolamo Di Giorgio

Research output: Contribution to journalArticlepeer-review


We describe a child with Prader-Willi syndrome (PWS) aged 3 years and 11 months who suddenly died 7 months after the initiation of GH therapy. The child never showed respiratory problems, but suffered from severe obesity. This case raises the question about the association between sudden death in children with PWS (with or without respiratory problems) and GH therapy, as already suspected in the recent past. We suggest that further epidemiological studies are required in order to determine more accurately the frequency of this causal connection and better understand its pathogenesis.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalHormone Research
Issue number1
Publication statusPublished - 2005


  • Growth hormone therapy
  • Prader-Willi syndrome
  • Sudden death

ASJC Scopus subject areas

  • Endocrinology


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