Sudden death in Prader-Willi syndrome during growth hormone therapy

Michele Sacco, Girolamo Di Giorgio

Research output: Contribution to journalArticle

Abstract

We describe a child with Prader-Willi syndrome (PWS) aged 3 years and 11 months who suddenly died 7 months after the initiation of GH therapy. The child never showed respiratory problems, but suffered from severe obesity. This case raises the question about the association between sudden death in children with PWS (with or without respiratory problems) and GH therapy, as already suspected in the recent past. We suggest that further epidemiological studies are required in order to determine more accurately the frequency of this causal connection and better understand its pathogenesis.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalHormone Research
Volume63
Issue number1
DOIs
Publication statusPublished - 2005

Fingerprint

Prader-Willi Syndrome
Sudden Death
Growth Hormone
Morbid Obesity
Epidemiologic Studies
Therapeutics

Keywords

  • Growth hormone therapy
  • Prader-Willi syndrome
  • Sudden death

ASJC Scopus subject areas

  • Endocrinology

Cite this

Sudden death in Prader-Willi syndrome during growth hormone therapy. / Sacco, Michele; Di Giorgio, Girolamo.

In: Hormone Research, Vol. 63, No. 1, 2005, p. 29-32.

Research output: Contribution to journalArticle

Sacco, Michele ; Di Giorgio, Girolamo. / Sudden death in Prader-Willi syndrome during growth hormone therapy. In: Hormone Research. 2005 ; Vol. 63, No. 1. pp. 29-32.
@article{935d158bc82d4c7dbae3fa29b641820c,
title = "Sudden death in Prader-Willi syndrome during growth hormone therapy",
abstract = "We describe a child with Prader-Willi syndrome (PWS) aged 3 years and 11 months who suddenly died 7 months after the initiation of GH therapy. The child never showed respiratory problems, but suffered from severe obesity. This case raises the question about the association between sudden death in children with PWS (with or without respiratory problems) and GH therapy, as already suspected in the recent past. We suggest that further epidemiological studies are required in order to determine more accurately the frequency of this causal connection and better understand its pathogenesis.",
keywords = "Growth hormone therapy, Prader-Willi syndrome, Sudden death",
author = "Michele Sacco and {Di Giorgio}, Girolamo",
year = "2005",
doi = "10.1159/000082525",
language = "English",
volume = "63",
pages = "29--32",
journal = "Hormone Research",
issn = "0301-0163",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Sudden death in Prader-Willi syndrome during growth hormone therapy

AU - Sacco, Michele

AU - Di Giorgio, Girolamo

PY - 2005

Y1 - 2005

N2 - We describe a child with Prader-Willi syndrome (PWS) aged 3 years and 11 months who suddenly died 7 months after the initiation of GH therapy. The child never showed respiratory problems, but suffered from severe obesity. This case raises the question about the association between sudden death in children with PWS (with or without respiratory problems) and GH therapy, as already suspected in the recent past. We suggest that further epidemiological studies are required in order to determine more accurately the frequency of this causal connection and better understand its pathogenesis.

AB - We describe a child with Prader-Willi syndrome (PWS) aged 3 years and 11 months who suddenly died 7 months after the initiation of GH therapy. The child never showed respiratory problems, but suffered from severe obesity. This case raises the question about the association between sudden death in children with PWS (with or without respiratory problems) and GH therapy, as already suspected in the recent past. We suggest that further epidemiological studies are required in order to determine more accurately the frequency of this causal connection and better understand its pathogenesis.

KW - Growth hormone therapy

KW - Prader-Willi syndrome

KW - Sudden death

UR - http://www.scopus.com/inward/record.url?scp=12544259574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12544259574&partnerID=8YFLogxK

U2 - 10.1159/000082525

DO - 10.1159/000082525

M3 - Article

C2 - 15583479

AN - SCOPUS:12544259574

VL - 63

SP - 29

EP - 32

JO - Hormone Research

JF - Hormone Research

SN - 0301-0163

IS - 1

ER -