Sufentanil-propofol vs remifentanil-propofol during total intravenous anesthesia for neurosurgery. A multicentre study

P. P. Martorano, F. Aloj, S. Baietta, A. Fiorelli, M. Munari, F. Paccagnella, G. Rosa, M. Scafuro, E. Zei, Gabriele Falzetti, P. Pelaia

Research output: Contribution to journalArticlepeer-review


Background. In a randomised, prospective multi-centre study, we compared the intraoperative and postoperative effects of two opioids: sufentanil and remifentanil, in combination with propofol in two groups of patients undergoing neurosurgery. Methods. After Local Ethics Committee approval and informed consent obtaining, 69 patients undergoing neurosurgery for supratentorial tumours, between 18 and 75 years of age were randomised to receive either sufentanil or remifentanil in combination with propofol. Intraoperative and postoperative haemodynamic variables, recovery times (time to eye opening and to extubation), the incidence of postoperative respiratory depression, pain, nausea and vomiting were also evaluated. The Short Orientation-Memory-Concentration Test was used to evaluate cognitive function at 15, 45 and 180 min after emergence from anesthesia. Results. There were no significant differences between the groups in the duration of surgery and anesthesia, mean arterial pressure, heart rate, time to eye opening or extubation. The incidence of vomiting, respiratory depression and shivering was similar in both groups. Postoperative pain requiring supplemental analgesics was significantly lower in the sufentanil group (P

Original languageEnglish
Pages (from-to)233-243
Number of pages11
JournalMinerva Anestesiologica
Issue number6
Publication statusPublished - Jun 2008


  • Anesthesia
  • Intravenous
  • Neurosurgery
  • Psychological tests
  • Remifentanil
  • Sufentanil

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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