SUGGESTIONS POUR UN ROLE POSSIBLE DES RADICAUX OXYGENES LIBRES DANS LES ANOMALIES DE LA VASOMOTION ARTERIELLE CHEZ LES DIABETIQUES INSULINO-DEPENDANTS

A. Ceriello, A. Quatrado, F. Caretta, R. Varano, D. Giugliano

Research output: Contribution to journalArticle

Abstract

A functional arterial spasm, revealed by reduced postischemic response, is present in diabetic subjects with no overt evidence of vascular damage. The administration of three different antioxidant agents, vitamin C, thiopronine and glutathione, produces an increase of basal blood flow in both diabetic and normal subjects, and ameliorates significantly the vascular functional response in diabetes. These data suggest that free radicals may play a role in the regulation of arterial resistance in humans, and that a de-regulation of their action may be involved in the development of arterial dysfunction in diabetes.

Original languageEnglish
Pages (from-to)318-322
Number of pages5
JournalDiabete et Metabolisme
Volume16
Issue number4
Publication statusPublished - 1990

Keywords

  • Arterial vasomotion
  • Insulin-dependent diabetes
  • Oxygen free radicals

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Fingerprint Dive into the research topics of 'SUGGESTIONS POUR UN ROLE POSSIBLE DES RADICAUX OXYGENES LIBRES DANS LES ANOMALIES DE LA VASOMOTION ARTERIELLE CHEZ LES DIABETIQUES INSULINO-DEPENDANTS'. Together they form a unique fingerprint.

  • Cite this