Suggestive evidence for association of D2S2188 marker (2q31.1) with autism in 143 Sicilian (Italian) TRIO families

Valentino Romano, Francesco Calí, Gregorio Seidita, Mario Mirisola, Rosalba P. D'Anna, Giovanna Gambino, Pietro Schinocca, Salvatore Romano, Giovanni F. Ayala, Fabio Canziani, Giacomo De Leo, Maurizio Elia

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have screened 143 Sicilian (Italian) families with one autistic child to verify, by a linkage disequilibrium approach, the involvement of the 2q31.1 region in the cause of the disease in these families. Our study design includes the use of intrafamilial association to prevent a population stratification bias and ethnic homogeneity of the sample. The results of our analysis provided suggestive evidence of the occurrence of transmission disequilibrium between autism and the D2S2188 polymorphism in Sicilian TRIO families, a finding which provides further and independent support to the hypothesis of the existence of a susceptibility gene (or genes) for autism on chromosome 2q.

Original languageEnglish
Pages (from-to)149-150
Number of pages2
JournalPsychiatric Genetics
Volume15
Issue number2
DOIs
Publication statusPublished - Jun 2005

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Autistic Disorder
Linkage Disequilibrium
Genes
Chromosomes
Population

Keywords

  • Association study
  • Autism spectrum disorders
  • Extended transmission disequilibrium test
  • Linkage disequilibrium
  • Multiallelic transmission disequilibrium test

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

Cite this

Suggestive evidence for association of D2S2188 marker (2q31.1) with autism in 143 Sicilian (Italian) TRIO families. / Romano, Valentino; Calí, Francesco; Seidita, Gregorio; Mirisola, Mario; D'Anna, Rosalba P.; Gambino, Giovanna; Schinocca, Pietro; Romano, Salvatore; Ayala, Giovanni F.; Canziani, Fabio; De Leo, Giacomo; Elia, Maurizio.

In: Psychiatric Genetics, Vol. 15, No. 2, 06.2005, p. 149-150.

Research output: Contribution to journalArticle

Romano, V, Calí, F, Seidita, G, Mirisola, M, D'Anna, RP, Gambino, G, Schinocca, P, Romano, S, Ayala, GF, Canziani, F, De Leo, G & Elia, M 2005, 'Suggestive evidence for association of D2S2188 marker (2q31.1) with autism in 143 Sicilian (Italian) TRIO families', Psychiatric Genetics, vol. 15, no. 2, pp. 149-150. https://doi.org/10.1097/00041444-200506000-00013
Romano, Valentino ; Calí, Francesco ; Seidita, Gregorio ; Mirisola, Mario ; D'Anna, Rosalba P. ; Gambino, Giovanna ; Schinocca, Pietro ; Romano, Salvatore ; Ayala, Giovanni F. ; Canziani, Fabio ; De Leo, Giacomo ; Elia, Maurizio. / Suggestive evidence for association of D2S2188 marker (2q31.1) with autism in 143 Sicilian (Italian) TRIO families. In: Psychiatric Genetics. 2005 ; Vol. 15, No. 2. pp. 149-150.
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