Suicidal ideation and suicidal attempts in referred adolescents with high functioning autism spectrum disorder and comorbid bipolar disorder: A pilot study: Brain Sciences

G. Masi, S. Scullin, A. Narzisi, P. Muratori, M. Paciello, D. Fabiani, F. Lenzi, M. Mucci, G. D'acunto

Research output: Contribution to journalArticlepeer-review

Abstract

Suicidal ideation and attempts in adolescents are closely associated to bipolar disorders (BD). Growing evidence also suggests that high functioning autism spectrum disorders (HF-ASD) are at increased risk for suicidal ideation and behaviors. Although BD and HF-ASD are frequently comorbid, no studies explored suicidality in these individuals. This exploratory study addressed this issue in a clinical group of inpatient adolescents referred to a psychiatric emergency unit. Seventeen adolescents with BD and HF-ASD and severe suicidal ideation or attempts (BD-ASD-S), were compared to 17 adolescents with BD and HF-ASD without suicidal ideation or attempts (BD-ASD-noS), and to 18 adolescents with BD and suicidal ideation or attempts without ASD (BD-noASD-S), using a structured assessment methodology. Individuals with BD-ASD-S had a higher intelligence quotient, more severe clinical impairment, more lethality in suicide attempts, more internalizing symptoms, less impulsiveness, and lower social competence. Severity of ASD traits in individuals and parents did not correlate with suicidal risk. Some dimensions of resilience were protective in terms of repulsion by life and attraction to death. Main limitations are the small sample size, the lack of a control group of typically developing adolescents. However, a better understanding of the specificities of bipolar HF-ASD individuals with suicidality may improve prevention and treatment strategies. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalBrain Sci.
Volume10
Issue number10
DOIs
Publication statusPublished - 2020

Keywords

  • Adolescence
  • Autism spectrum disorder
  • Bipolar disorder
  • Suicidal attempts
  • Suicidal ideation
  • adolescent
  • aggression
  • anxiety
  • Article
  • autism
  • Autism Diagnostic Observation Schedule
  • Barratt Impulsiveness Scale 11
  • bipolar disorder
  • Child Behavior Checklist
  • Child Global Assessment Scale
  • Clinical Global Impression scale
  • Columbia Suicide Severity Rating Scale
  • comparative study
  • depression
  • disease severity
  • female
  • human
  • human experiment
  • impulsiveness
  • major clinical study
  • male
  • mental function assessment
  • Multi Attitude Suicide Tendency Scale
  • normal human
  • Perceptual Reasoning Index
  • pilot study
  • Processing Speed Index
  • psychological resilience scale
  • social competence
  • suicidal behavior
  • suicidal ideation
  • suicide attempt
  • Verbal Comprehension index
  • Wechsler intelligence scale
  • Working Memory Index

Fingerprint

Dive into the research topics of 'Suicidal ideation and suicidal attempts in referred adolescents with high functioning autism spectrum disorder and comorbid bipolar disorder: A pilot study: Brain Sciences'. Together they form a unique fingerprint.

Cite this