Suicide Attempts in Juvenile Bipolar Versus Major Depressive Disorders: Systematic Review and Meta-Analysis

Franco De Crescenzo, Giulia Serra, Francesco Maisto, Mai Uchida, Hilary Woodworth, Maria Pia Casini, Ross J. Baldessarini, Stefano Vicari

Research output: Contribution to journalReview articlepeer-review


Objective Suicide attempts are prevalent in association with major mood disorders, and risk is greater with bipolar disorder (BD) than major depressive disorder (MDD) in adults. There may be similar relationships in juvenile mood disorders, but the evidence has not been compiled systematically and quantitatively. Method We searched for reports of studies comparing rates of suicide attempts in children or adolescents diagnosed with BD or MDD, and applied random-effects meta-analysis. Results In 6 reports from 1995 to 2017, with 2,303 participants diagnosed with mood disorder from the United States and South Korea, aged 3 to 18 years, rates of suicide attempts differed significantly by diagnosis: BD (31.5%) > MDD (20.5%) > hypomania or mania-only (8.49%). Risk of suicide attempts differed (BD > MDD) highly significantly by meta-analysis (odds ratio [OR] = 1.71, CI = 1.33–2.20, p <.0001), and was very similar if a study with attempts and suicidal ideation was excluded (OR = 1.64, CI = 1.26–2.15, p <.0001). Conclusion Risk of suicide attempts in juvenile mood disorder patients ranked: BD > MDD >> hypomania or mania-only >> juvenile general population.

Original languageEnglish
Pages (from-to)825-831.e3
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Issue number10
Publication statusPublished - Oct 1 2017


  • affective
  • bipolar
  • depression
  • meta-analysis
  • suicide attempt

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health


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