Suicide gene therapy for control of graft-versus-host disease

C. Bonini, C. Bordignon

Research output: Contribution to journalArticle

Abstract

In allogeneic bone marrow transplantation, donor lymphocytes contribute to the development of GvHD, but can also confer protection, through graft versus leukemia, facilitating engraftment, and providing antiviral immunity. Here, Chiara Bonini and Claudio Bordignon summarize how a suicide gene in the delayed infusion of donor lymphocytes may help separate the two effects of donor lymphocytes.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalImmunologist
Volume7
Issue number3
Publication statusPublished - 1999

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Graft vs Host Disease
Genetic Therapy
Suicide
Lymphocytes
Homologous Transplantation
Bone Marrow Transplantation
Antiviral Agents
Immunity
Leukemia
Transplants
Genes

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Suicide gene therapy for control of graft-versus-host disease. / Bonini, C.; Bordignon, C.

In: Immunologist, Vol. 7, No. 3, 1999, p. 93-97.

Research output: Contribution to journalArticle

Bonini, C. ; Bordignon, C. / Suicide gene therapy for control of graft-versus-host disease. In: Immunologist. 1999 ; Vol. 7, No. 3. pp. 93-97.
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