Suicide gene therapy to increase the safety of chimeric antigen receptor-redirected T lymphocytes

Monica Casucci, Attilio Bondanza

Research output: Contribution to journalArticlepeer-review

Abstract

Chimeric antigen receptors (CARs) are generated by fusing the antigen-binding motif of a monoclonal antibody (mAb) with the signal transduction machinery of the T-cell receptor (TCR). The genetic modification of T lymphocytes with chimeric receptors specific for tumor-associated antigens (TAAs) allows for the redirection towards tumor cells. Clinical experience with CAR-redirected T cells suggests that antitumor efficacy associates with some degree of toxicity, especially when TAA expression is shared with healthy tissues. This situation closely resembles the case of allogeneic hematopoietic stem cell transplantation (HSCT), wherein allorecognition causes both the graft-versus-leukemia (GVL) effect and graft-versus-host disease (GVHD). Suicide gene therapy, i.e. the genetic induction of a conditional suicide phenotype into donor T cells, enables dissociating the GVL effect from GVHD. Applying suicide gene modification to CAR-redirected T cells may therefore greatly increase their safety profile and facilitate their clinical development.

Original languageEnglish
Pages (from-to)378-382
Number of pages5
JournalJournal of Cancer
Volume2
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • Chimeric antigen receptors
  • Suicide gene therapy

ASJC Scopus subject areas

  • Oncology

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